Bats and birds live substantially longer on average than non-flying mammals of similar body
size. The combination of small body size, high metabolic rates, and long lifespan in bats and …

Bat biologists have long known about the exceptional longevity of bats (Order: Chiroptera),
which is unusual for mammals of such a small size and a high metabolic rate. Yet relatively …

The extended longevity of bats, despite their high metabolic rate, may provide insight to
patterns and mechanisms of aging. Here I test predictions of the free radical or oxidative …

The evolutionary theory of aging predicts that life span should decrease in response to the
amount of mortality caused by extrinsic sources. Using this prediction, we selected six life …

Bats are the longest-lived mammals, given their body size. However, the underlying
molecular mechanisms of their extended healthspans are poorly understood. To address …

Understanding aging is a grand challenge in biology. Exceptionally long-lived animals have
mechanisms that underpin extreme longevity. Telomeres are protective nucleotide repeats …

Much of the current research on longevity focuses on the aging process within a single
species. Several molecular players (eg IGF1 and MTOR), pharmacological compounds (eg …

Many laboratory models used in aging research are inappropriate for understanding
senescence in mammals, including humans, because of fundamental differences in life …

The long life spans and slow aging rates of birds relative to mammals are paradoxical in
view of birds' high metabolic rates, body temperatures and blood glucose levels, all of which …

Despite their high lifetime energy expenditures, most birds can be characterized as long-
lived homeotherms with moderately slow aging. A growing body of research confirms the …