Altered structure, and hence function, of cellular macromolecules caused by oxidation can
contribute to loss of physiological function with age. Here, we tested whether the lifespan of …

Here we review the examples of great longevity and potential immortality in the earliest
animal types and contrast and compare these to humans and other higher animals. We start …

In most animal taxa, longevity increases with body size across species, as predicted by the
oxidative stress theory of aging. In contrast, in within-species comparisons of mammals and …

Recent results indicate that the longevity of both invertebrates and vertebrates can be
altered through genetic manipulation and pharmacological intervention. Most of these …

Oxidative stress is suggested as a contributor to the ageing process. Knowledge of the
relationship between age and energy expenditure may contribute to our understanding of …

The links between energy expenditure and ageing are different at different levels of enquiry.
When studies have examined the relationships between different species within a given …

For vertebrates, body mass underlies much of the variation in metabolism, but among
animals of the same body mass, metabolism varies six-fold. Understanding how natural …

Aging is a complex process that affects multiple organs. Modeling aging and age-related
diseases in the lab is challenging because classical vertebrate models have relatively long …

Survival probability is predicted to underlie the evolution of life histories along a slow–fast
continuum. Hibernation allows a diverse range of small mammals to exhibit seasonal …

Actuarial senescence in captive populations of 28 species of bird was quantified by
estimating the parameters of Weibull models fitted to survival curves constructed from data …