Transcriptomic analysis reveals sex-specific patterns in the hippocampus in Alzheimer's disease

A Onisiforou, CC Christodoulou… - Frontiers in …, 2024 - frontiersin.org
Background The hippocampus, vital for memory and learning, is among the first brain
regions affected in Alzheimer's Disease (AD) and exhibits adult neurogenesis. Women face …

Sex differences in hippocampal β-amyloid accumulation in the triple-transgenic mouse model of Alzheimer's disease and the potential role of local estrogens

YT Hu, XL Chen, YN Zhang, H McGurran… - Frontiers in …, 2023 - frontiersin.org
Introduction Epidemiological studies show that women have a higher prevalence of
Alzheimer's disease (AD) than men. Peripheral estrogen reduction during aging in women is …

Mechanisms of sex differences in Alzheimer's disease

C Lopez-Lee, ERS Torres, G Carling, L Gan - Neuron, 2024 - cell.com
Alzheimer's disease (AD) and the mechanisms underlying its etiology and progression are
complex and multifactorial. The higher AD risk in women may serve as a clue to better …

Transcriptome meta-analysis reveals a central role for sex steroids in the degeneration of hippocampal neurons in Alzheimer's disease

JM Winkler, HS Fox - BMC systems biology, 2013 - Springer
Background Alzheimer's disease is the most prevalent form of dementia. While a number of
transcriptomic studies have been performed on the brains of Alzheimer's specimens, no …

Sex-specific transcriptional rewiring in the brain of Alzheimer's disease patients

JA Santiago, JP Quinn, JA Potashkin - Frontiers in Aging …, 2022 - frontiersin.org
Sex-specific differences may contribute to Alzheimer's disease (AD) development. AD is
more prevalent in women worldwide, and female sex has been suggested as a disease risk …

[HTML][HTML] An integrated approach to identifying sex-specific genes, transcription factors, and pathways relevant to Alzheimer's disease

A López-Cerdán, Z Andreu, MR Hidalgo… - Neurobiology of …, 2024 - Elsevier
Background Age represents a significant risk factor for the development of Alzheimer's
disease (AD); however, recent research has documented an influencing role of sex in …

Alzheimer's pathogenic mechanisms and underlying sex difference

D Zhu, A Montagne, Z Zhao - Cellular and Molecular Life Sciences, 2021 - Springer
AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …

Sex specific molecular networks and key drivers of Alzheimer's disease

L Guo, J Cao, J Hou, Y Li, M Huang, L Zhu… - Molecular …, 2023 - Springer
Background Alzheimer's disease (AD) is a progressive and age-associated
neurodegenerative disorder that affects women disproportionally. However, the underlying …

[HTML][HTML] Sex differences in Alzheimer's disease: insights from the multiomics landscape

L Guo, MB Zhong, L Zhang, B Zhang, D Cai - Biological psychiatry, 2022 - Elsevier
Alzheimer's disease (AD) has complex etiologies, and the impact of sex on AD varies over
the course of disease development. The literature provides some evidence of sex-specific …

Estrogen signaling in Alzheimer's disease: molecular insights and therapeutic targets for Alzheimer's dementia

MS Uddin, MM Rahman, M Jakaria, MS Rahman… - Molecular …, 2020 - Springer
Estrogens play a crucial physiological function in the brain; however, debates exist
concerning the role of estrogens in Alzheimer's disease (AD). Women during pre-, peri-, or …