Simple Summary Abnormal DNA methylation is known to regulate gene expression, and its
features have been frequently observed in colorectal cancer (CRC) patients. In addition …

Despite the recent advances in the therapeutic modalities, colorectal cancer (CRC) remains
to be one of the most common causes of cancer-related death. CRC arises through …

DNA methylation is one of the earliest and most significant epigenetic mechanisms
discovered. DNA methylation refers, in general, to the addition of a methyl group to a specific …

Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …

Background/aim The gradual accumulation of genetic and epigenetic alterations can lead to
the development of colorectal cancer. In the last decade much research has been done to …

Increasing evidence indicates the high heterogeneity of cancer cells. Recent studies have
revealed distinct subtypes of DNA methylation in colorectal cancer (CRC); however, the …

Epigenetic alterations, including DNA methylation, histone modification, loss of genome
imprinting, chromatin remodeling and noncoding RNAs, are associated with human …

Recent studies show that colorectal cancer is strongly associated with aberrant DNA
methylation, which has been linked to the origin and progression of the disease. This fact …

Previous studies have indicated that abnormal methylation is a critical and early event in the
pathogenesis of most types of human cancer, which contributes to tumorigenesis. However …

Aim: Gain insight about the role of DNA methylation in the malignant growth of colon cancer.
Patients & methods: Methylation and gene expression from 90 adjacent-tumor paired tissues …