Aberrant methylation of promoter CpG islands in cancer is associated with silencing of tumor-
suppressor genes, and age-dependent hypermethylation in normal appearing mucosa may …

We have developed a transcriptome-wide approach to identify genes affected by promoter
CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By …

The normal aging process is a complex phenomenon associated with physiological
alterations in the function of cells and organs over time. Although an attractive candidate for …

Background Global but predictable changes impact the DNA methylome as we age, acting
as a type of molecular clock. This clock can be hastened by conditions that decrease …

DNA methylation of promoter-associated CpG islands may function as an alternate
mechanism of silencing tumor suppressor genes in multiple neoplasias including colorectal …

In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in
repressive histone post-translational modifications. However, the chromatin marks …

Aging is the most important risk factor for the development of most adult malignancies. The
molecular events responsible for this striking association remain under investigation, but …

DNA methylation plays an important role in development of disease and the process of
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …

In our study, whole‐genome methylation arrays were applied to identify novel genes with
tumor specific DNA methylation of promoter CpG islands in pre‐malignant and malignant …

Abstract Changes in DNA methylation, whether hypo‐or hypermethylation, have been
shown to be associated with the progression of colorectal cancer. Methylation changes …