Methylation-regulated long non-coding RNA expression in ulcerative colitis

CG Fenton, MK Ray, W Meng, RH Paulssen - International Journal of …, 2023 - mdpi.com
Long non-coding RNAs (lncRNAs) have been shown to play a role in the pathogenesis of
ulcerative colitis (UC). Although epigenetic processes such as DNA methylation and lncRNA …

[HTML][HTML] Novel long non-coding RNAs of relevance for ulcerative colitis pathogenesis

MK Ray, CG Fenton, RH Paulssen - Non-coding RNA Research, 2022 - Elsevier
Background and aims The study aimed to identify yet unknown and uncharacterized long
non-coding RNAs (lncRNAs) in treatment-naïve ulcerative colitis (UC), and to define their …

m6A Methylated Long Noncoding RNA LOC339803 Regulates Intestinal Inflammatory Response

A Olazagoitia‐Garmendia, H Rojas‐Márquez… - Advanced …, 2024 - Wiley Online Library
Cytokine mediated sustained inflammation increases the risk to develop different complex
chronic inflammatory diseases, but the implicated mechanisms remain unclear. Increasing …

A systematic review of the role of DNA methylation on inflammatory genes in ulcerative colitis

NJD Gould, KLM Davidson, CU Nwokolo… - …, 2016 - Taylor & Francis
Background: Ulcerative colitis (UC) is an idiopathic disease of the large intestine with
evidence pointing to the role of epigenetic changes. Methods: Searches were performed in …

DNA hypo-methylation facilitates anti-inflammatory responses in severe ulcerative colitis

H Taman, CG Fenton, E Anderssen, J Florholmen… - PLoS …, 2021 - journals.plos.org
Severe ulcerative colitis (UC) is a potentially life-threatening disease with a potential
colorectal cancer (CRC) risk. The aim of this study was to explore the relationship between …

A genome-wide methylation approach identifies a new hypermethylated gene panel in ulcerative colitis

K Kang, JH Bae, K Han, ES Kim, TO Kim… - International journal of …, 2016 - mdpi.com
The cause of inflammatory bowel disease (IBD) is still unknown, but there is growing
evidence that environmental factors such as epigenetic changes can contribute to the …

Integrated analysis of DNA methylation and gene expression profiles identified S100A9 as a potential biomarker in ulcerative colitis

S Su, W Kong, J Zhang, X Wang, H Guo - Bioscience Reports, 2020 - portlandpress.com
Ulcerative colitis (UC) is a prevalent relapsing-remitting inflammatory bowel disease whose
pathogenetic mechanisms remain elusive. In the present study, colonic biopsies samples …

Epigenetic regulation and therapeutic strategies in ulcerative colitis

L Yan, C Gu, S Gao, B Wei - Frontiers in Genetics, 2023 - frontiersin.org
Ulcerative colitis (UC) is an inflammatory bowel disease, and is characterized by the diffuse
inflammation and ulceration in the colon and rectum mucosa, even extending to the caecum …

Ulcerative colitis-associated long noncoding RNA, BC012900, regulates intestinal epithelial cell apoptosis

F Wu, Y Huang, F Dong, JH Kwon - Inflammatory Bowel …, 2016 - academic.oup.com
Background Long noncoding RNAs (lncRNAs) were recently found to be key regulators of
biological functions and associated with human diseases. Thus far, the roles of lncRNAs in …

DNA methylation fine-tunes pro-and anti-inflammatory signalling pathways in inactive ulcerative colitis tissue biopsies

W Meng, CG Fenton, KM Johnsen, H Taman… - Scientific Reports, 2024 - nature.com
DNA methylation has been implied to play a role in the immune dysfunction associated with
inflammatory bowel disease (IBD) and the disease development of ulcerative colitis (UC) …