Identified S100A9 as a target for diagnosis and treatment of ulcerative colitis by bioinformatics analysis

L Tan, X Li, H Qin, Q Zhang, J Wang, T Chen… - Scientific Reports, 2024 - nature.com
Ulcerative colitis (UC) is a chronic, recurrent inflammatory bowel disease. UC confronts with
severe challenges including the unclear pathogenesis and lack of specific diagnostic …

[HTML][HTML] Identification of immune-related hub genes contributing to the pathogenesis, diagnosis, and remission of ulcerative colitis by integrated bioinformatic analyses

L Zhou, Q Gu, A Huang, G Fu, X Hu, Z Jiang - Medicine, 2023 - journals.lww.com
The inflammatory disease ulcerative colitis (UC) is multifaceted, immune-mediated, chronic,
and relapsing, which is considered to be mainly driven by dysregulated mucosal immune …

[HTML][HTML] Biomarkers prediction and immune landscape in ulcerative colitis: Findings based on bioinformatics and machine learning

Y Yang, Y Hua, H Zheng, R Jia, Z Ye, G Su, Y Gu… - Computers in Biology …, 2024 - Elsevier
Background Ulcerative colitis (UC) presents diagnostic and therapeutic difficulties. The
primary objective of this study is to identify efficacious biomarkers for diagnosis and …

Screening of ulcerative colitis biomarkers and potential pathways based on weighted gene co-expression network, machine learning and ceRNA hypothesis

Y Li, M Tang, FJ Zhang, Y Huang, J Zhang, J Li… - Hereditas, 2022 - Springer
Background Ulcerative colitis (UC) refers to an intractable intestinal inflammatory disease. Its
increasing incidence rate imposes a huge burden on patients and society. The UC etiology …

Analysis of genes involved in ulcerative colitis activity and tumorigenesis through systematic mining of gene co-expression networks

W Shi, R Zou, M Yang, L Mai, J Ren, J Wen… - Frontiers in …, 2019 - frontiersin.org
Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disorder of the colon,
characterized by continuous mucosal inflammation. Recently, some studies have …

[HTML][HTML] Identifying biomarkers associated with the diagnosis of ulcerative colitis via bioinformatics and machine learning

Y Wang, J Huang, J Zhang, F Wang… - Mathematical …, 2023 - aimspress.com
Two datasets (GSE87473 and GSE92415) were merged to obtain 193 UC samples and 42
normal samples. Using R, differentially expressed genes (DEGs) between UC and normal …

Integrative computational approach identifies immune‐relevant biomarkers in ulcerative colitis

T He, K Wang, P Zhao, G Zhu, X Yin, Y Zhang… - FEBS Open …, 2022 - Wiley Online Library
Ulcerative colitis is a common inflammatory bowel disease with a complex genetic and
immune etiology. Immune infiltration plays a vital role in the development of ulcerative colitis …

Biomarkers of ulcerative colitis disease activity CXCL1, CYP2R1, LPCAT1, and NEU4 and their relationship to immune infiltrates

A Huo, F Wang - Scientific Reports, 2023 - nature.com
The diagnosis and assessment of ulcerative colitis (UC) poses significant challenges, which
may result in inadequate treatment and a poor prognosis for patients. This study aims to …

Investigation of potential genetic biomarkers and molecular mechanism of ulcerative colitis utilizing bioinformatics analysis

J Zhang, X Wang, L Xu, Z Zhang… - BioMed Research …, 2020 - Wiley Online Library
Objectives. To reveal the molecular mechanisms of ulcerative colitis (UC) and provide
potential biomarkers for UC gene therapy. Methods. We downloaded the GSE87473 …

Identification of Critical Modules and Biomarkers of Ulcerative Colitis by Using WGCNA

Y Yuan, N Li, M Fu, M Ye - Journal of inflammation research, 2023 - Taylor & Francis
Background Ulcerative colitis (UC) is a chronic inflammatory disease of the colon and
rectum that has no exact cause and is characterized by relapsing and remitting episodes …