The world population is undergoing a rapid expansion of older adults. Aging is associated
with numerous changes that affect all organs and systems, including every component of the …

The reduced efficiency of the mammalian immune system with aging increases host
susceptibility to infectious and autoimmune diseases. However, the mechanisms …

Objective Aging has been reported to be associated with changes in immune function.
Although frequent infection and the development of malignancy suggest the decline of …

T cell ageing has a pivotal role in rendering older individuals vulnerable to infections and
cancer and in impairing the response to vaccination. Easy accessibility to peripheral human …

Decreased immune responsiveness associated with aging is generally termed
“immunosenescence”. Several theories have been proposed to explain age-related declines …

Age-related alterations in immunity have been linked to increased incidence of infections
and decreased responses to vaccines in the aging population. Human peripheral blood …

Changes to innate cells, such as macrophages and myeloid‐derived suppressor cells
(MDSC s), during aging in healthy or tumor‐bearing hosts are not well understood. We …

Systematic understanding of immune aging on a whole-body scale is currently lacking. We
characterized age-associated alterations in immune cells across multiple mouse organs …

Aging is associated with a gradual loss of naïve T cells and a reciprocal increase in the
proportion of memory T cells. While reduced thymic output is important, age-dependent …

The immune system exhibits profound age-related changes, collectively termed
immunosenescence. The most visible of these is the decline in protective immunity, which …