The effect of age on mortality in patients with COVID-19: a meta-analysis with 611,583 subjects

C Bonanad, S García-Blas… - Journal of the American …, 2020 - Elsevier
Objectives Initial data on COVID-19 infection has pointed out a special vulnerability of older
adults. Design We performed a meta-analysis with available national reports on May 7, 2020 …

[HTML][HTML] Changing age distribution of the COVID-19 pandemic—United States, May–August 2020

TK Boehmer - MMWR. Morbidity and mortality weekly report, 2020 - cdc.gov
During June–August 2020, COVID-19 incidence was highest in persons aged 20–29 years,
who accounted for> 20% of all confirmed cases. Younger adults likely contribute to …

How have older adults reacted to coronavirus disease 2019?

A Cigiloglu, ZA Ozturk, EM Efendioglu - Psychogeriatrics, 2021 - Wiley Online Library
Aim Outbreaks have a wide spectrum of psychosocial impact on individuals. This study
aimed to investigate the psychosocial effects of measures to prevent the spread of the novel …

[HTML][HTML] COVID-19: a geriatric emergency

V Boccardi, C Ruggiero, P Mecocci - Geriatrics, 2020 - mdpi.com
The older Italian population is posing a challenge in the number of deaths for coronavirus
disease 2019 (COVID-19). According to previous data from China, pre-existing health …

Age-associated SARS-CoV-2 breakthrough infection and changes in immune response in a mouse model

Y Chen, C Li, F Liu, Z Ye, W Song… - Emerging Microbes & …, 2022 - Taylor & Francis
Older individuals are at higher risk of SARS-CoV-2 infection and severe outcomes, but the
underlying mechanisms are incompletely understood. In addition, how age modulates SARS …

[HTML][HTML] Exploring the relevance of senotherapeutics for the current SARS-CoV-2 emergency and similar future global health threats

M Malavolta, R Giacconi, D Brunetti, M Provinciali… - Cells, 2020 - mdpi.com
The higher death rate caused by COVID-19 in older people, especially those with
comorbidities, is a challenge for biomedical aging research. Here we explore the idea that …

COVID‐19 presents high risk to older persons

WB Applegate, JG Ouslander - Journal of the American Geriatrics …, 2020 - ncbi.nlm.nih.gov
The worldwide spread of COVID-19 is alarming to all of us and has created an enormous
public health and clinical crisis. Emerging data indicate that COVID-19 is a particular risk for …

[HTML][HTML] Covid-19 and immunity in aging populations—a new research agenda

WC Koff, MA Williams - New England Journal of Medicine, 2020 - Mass Medical Soc
Covid-19 and Immunity in Aging Populations As billions of dollars flow into research and
development efforts aimed at controlling SARS-CoV-2, the pandemic response remains …

Underlying vulnerabilities to the cytokine storm and adverse COVID-19 outcomes in the aging immune system

LS Nidadavolu, JD Walston - The Journals of Gerontology …, 2021 - academic.oup.com
Older adults are far more vulnerable to adverse health outcomes and mortality after
contracting COVID-19. There are likely multiple age-related biological, clinical, and …

[HTML][HTML] Can an effective SARS-CoV-2 vaccine be developed for the older population?

G Pawelec, N Weng - Immunity & Ageing, 2020 - Springer
The emergence of SARS-CoV-2 and its inordinately rapid spread is posing severe
challenges to the wellbeing of millions of people worldwide, health care systems and the …