Variation in human lifespan is 20 to 30% heritable in twins but few genetic variants have
been identified. We undertook a Genome Wide Association Study (GWAS) using age at …

We undertook a genome-wide association study (GWAS) of parental longevity in European
descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci …

Background Family studies and heritability estimates provide evidence for a genetic
contribution to variation in the human life span. Methods We conducted a genome wide …

Complex diseases are major contributors to human mortality in old age. Paradoxically, many
genetic variants that have been associated with increased risks of such diseases are found …

Research into the genetic component of human longevity can provide important insights in
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …

The genetic contribution to the variation in human lifespan is∼ 25%. Despite the large
number of identified disease-susceptibility loci, it is not known which loci influence …

Aging populations face diminishing quality of life due to increased disease and morbidity.
These challenges call for longevity research to focus on understanding the pathways …

Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

Background Lifestyle and longevity genes have different and important roles in the human
lifespan; however, the association between a healthy lifestyle in late-life and life expectancy …

Several studies on the genetics of longevity have been reviewed in this paper. The results
show that, despite efforts and new technologies, only two genes, APOE and FOXO3A …