There is an intense search for longevity genes in both animal models and humans. Human
family studies have indicated that a modest amount of the overall variation in adult lifespan …

The New England Centenarian Study (NECS) was founded in 1994 as a longitudinal study
of centenarians to determine if centenarians could be a model of healthy human aging. Over …

In anticipation of the sequencing of the human genome and description of the human
proteome, the Age, Gene/Environment Susceptibility–Reykjavik Study (AGES–Reykjavik) …

Ageing in humans is typified by the decline of physiological functions in various organs and
tissues leading to an increased probability of death. Some individuals delay, escape or …

Previous twin studies have indicated that approximately 25% of the variation in life span can
be attributed to genetic factors and recent studies have also suggested a moderate …

Human longevity is a complex trait, and to disentangle its basis has a great theoretical and
practical consequences for biomedicine. The genetics of human longevity is still poorly …

Genetic factors influence variation in human life span. The fast technological advancements
in genome research and the methodology for statistical analysis of complex traits provided …

Humans age at different rates and families with exceptional survival provide the opportunity
to understand why some people age slower than others. Unique features exhibited by …

The inherent complexity of aging‐related traits can temper progress in unraveling the
genetic origins of healthspan. We focus on two generations in the Framingham Heart Study …

Survival to extreme ages clusters within families. However, identifying genetic loci conferring
longevity and low morbidity in such longevous families is challenging. There is debate …