Background: Observational studies in older subjects have shown no or inverse associations
between cholesterol levels and mortality. However, in old age plasma low-density …

A recent paper by Deelen et al.(2014) in Human Molecular Genetics reports the largest
genome-wide association study of human longevity to date. While impressive, there is a …

Ageing phenotypes, such as years lived in good health (healthspan), total years lived
(lifespan), and survival until an exceptional old age (longevity), are of interest to us all but …

Alteration of single genes involved in nutrient and lipoprotein metabolism increases
longevity in several animal models. Because exceptional longevity in humans is familial, it is …

Many of the genes that affect aging and longevity in model organisms, such as mice, fruit
flies, and worms, have human homologs. This article reviews several genetic pathways that …

The search for the genetic determinants of extreme human longevity has been challenged
by the phenotype's rarity and its nonspecific definition by investigators. To address these …

As the world population ages, so the prevalence increases of individuals aged 100 years or
more, known as centenarians. Reaching this age has been described as exceptional …

In an effort to dissect the genetic components of longevity, we have undertaken case–control
studies of populations of centenarians (n= 338) and adults aged 20–70 years at several …

Lifespan is a trait of enormous personal interest. Research into the biological basis of
human lifespan, however, is hampered by the long time to death. Using a novel approach of …

The results of genome-wide association studies of complex traits, such as life span or age at
onset of chronic disease, suggest that such traits are typically affected by a large number of …