Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions

J Chen, B Ma, Y Yang, B Wang, J Hao, X Zhou - Biomarker Research, 2024 - Springer
Cell death is an important part of the life cycle, serving as a foundation for both the orderly
development and the maintenance of physiological equilibrium within organisms. This …

Disulfidptosis: a novel cell death modality induced by actin cytoskeleton collapse and a promising target for cancer therapeutics

T Li, Y Song, L Wei, X Song, R Duan - Cell Communication and Signaling, 2024 - Springer
Disulfidptosis is a novel discovered form of programmed cell death (PCD) that diverges from
apoptosis, necroptosis, ferroptosis, and cuproptosis, stemming from disulfide stress-induced …

Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications.

Q Gu, Y An, M Xu, X Huang, X Chen, X Li… - Aging and …, 2024 - europepmc.org
Programmed cell death is pivotal for several physiological processes, including immune
defense. Further, it has been implicated in the pathogenesis of developmental disorders and …

Disulfidptosis: A new type of cell death

F Xiao, HL Li, B Yang, H Che, F Xu, G Li, CH Zhou… - Apoptosis, 2024 - Springer
Disulfidptosis is a novel form of cell death that is distinguishable from established
programmed cell death pathways such as apoptosis, pyroptosis, autophagy, ferroptosis, and …

Inducing disulfidptosis in tumors: potential pathways and significance

T Mi, X Kong, M Chen, P Guo, D He - MedComm, 2024 - Wiley Online Library
Regulated cell death (RCD) is crucial for the elimination of abnormal cells. In recent years,
strategies aimed at inducing RCD, particularly apoptosis, have become increasingly …

[HTML][HTML] Disulfidptosis: Six Riddles Necessitating Solutions

X Wang, C Zheng, H Yao, Y Guo, Y Wang… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Disulfidptosis occurs as a result of the accumulation of intracellular cystine followed by
disulfide stress in actin cytoskeleton proteins due to a reduction of NADPH produced …

Disulfidptosis: a new form of regulated cell death for cancer treatment

Y Meng, X Chen, G Deng - Molecular biomedicine, 2023 - Springer
A recent study published in Nature Cell Biology demonstrated a novel type of regulated cell
death (RCD) termed disulfidptosis that is caused by excessive disulfide formation in actin …

[HTML][HTML] Molecular landmarks of tumor disulfidptosis across cancer types to promote disulfidptosis-target therapy

D Zhao, Y Meng, Y Dian, Q Zhou, Y Sun, J Le, F Zeng… - Redox Biology, 2023 - Elsevier
The mystery about the mechanistic basis of disulfidptosis has recently been unraveled and
shows promise as an effective treatment modality for triggering cancer cell death. However …

In what area of biology has a “new” type of cell death been discovered?

X Wang, J Lin, Z Li, M Wang - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Cell death is a fundamental physiological process that occurs in all organisms and is crucial
to each organism's evolution, ability to maintain a stable internal environment, and the …

[HTML][HTML] Disulfidptosis: Disulfide stress mediates a novel cell death pathway via actin cytoskeletal vulnerability

D Shao, L Shi, H Ji - Molecules and Cells, 2023 - ncbi.nlm.nih.gov
Disulfidptosis: Disulfide Stress Mediates a Novel Cell Death Pathway via Actin Cytoskeletal
Vulnerability - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …