Meta-analysis of human methylomes reveals stably methylated sequences surrounding CpG islands associated with high gene expression
Background DNA methylation is thought to play an important role in the regulation of
mammalian gene expression, partly based on the observation that a lack of CpG island …
mammalian gene expression, partly based on the observation that a lack of CpG island …
Tissue-specific variation in DNA methylation levels along human chromosome 1
Background DNA methylation is a major epigenetic modification important for regulating
gene expression and suppressing spurious transcription. Most methods to scan the genome …
gene expression and suppressing spurious transcription. Most methods to scan the genome …
Features of methylation and gene expression in the promoter‐associated CpG islands using human methylome data
CpG islands are typically located in the 5′ end of genes and considered as gene markers
because they play important roles in gene regulation via epigenetic change. In this study, we …
because they play important roles in gene regulation via epigenetic change. In this study, we …
Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome
DNA methylation is the most studied epigenetic mark and CpG methylation is central to
many biological processes and human diseases. Since cancer has highlighted the …
many biological processes and human diseases. Since cancer has highlighted the …
A DNA methylation fingerprint of 1628 human samples
AF Fernandez, Y Assenov, JI Martin-Subero… - Genome …, 2012 - genome.cshlp.org
Most of the studies characterizing DNA methylation patterns have been restricted to
particular genomic loci in a limited number of human samples and pathological conditions …
particular genomic loci in a limited number of human samples and pathological conditions …
Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters
The role of CpG island methylation in normal development and cell differentiation is of keen
interest, but remains poorly understood. We performed comprehensive DNA methylation …
interest, but remains poorly understood. We performed comprehensive DNA methylation …
Changes in correlation between promoter methylation and gene expression in cancer
Background Methylation of high-density CpG regions known as CpG Islands (CGIs) has
been widely described as a mechanism associated with gene expression regulation …
been widely described as a mechanism associated with gene expression regulation …
Linking the epigenome to the genome: correlation of different features to DNA methylation of CpG islands
DNA methylation of CpG islands plays a crucial role in the regulation of gene expression.
More than half of all human promoters contain CpG islands with a tissue-specific methylation …
More than half of all human promoters contain CpG islands with a tissue-specific methylation …
DNA methylation in human epigenomes depends on local topology of CpG sites
In vertebrates, methylation of cytosine at CpG sequences is implicated in stable and
heritable patterns of gene expression. The classical model for inheritance, in which …
heritable patterns of gene expression. The classical model for inheritance, in which …
“Same difference”: comprehensive evaluation of four DNA methylation measurement platforms
TJ Kacmarczyk, MP Fall, X Zhang, Y Xin, Y Li… - Epigenetics & …, 2018 - Springer
Background DNA methylation in CpG context is fundamental to the epigenetic regulation of
gene expression in higher eukaryotes. Changes in methylation patterns are implicated in …
gene expression in higher eukaryotes. Changes in methylation patterns are implicated in …