In human longevity studies, single nucleotide polymorphism (SNP) analysis identified a
large number of genetic variants with small effects, yet not easily replicable in different …

Twin studies have shown that longevity in humans is moderately heritable with a genetic
component of 25–32%. Experimental model organisms point to the existence of core …

Here we explore association with human longevity of common genetic variation in three
major candidate pathways: GH/IGF-1/insulin signaling, DNA damage signaling and repair …

Approximately one-quarter of the variation in lifespan in developed countries can be
attributed to genetic factors. However, even large population based studies investigating …

Longevity was influenced by many complex diseases and traits. However, the relationships
between human longevity and genetic risks of complex diseases were not broadly studied …

Despite notable progress of the candidate-gene and genome-wide association studies
(GWAS), understanding the role of genes contributing to human health and lifespan is still …

Ample evidence from model organisms has indicated that subtle variation in genes can
dramatically influence lifespan. The key genes and molecular pathways that have been …

Human lifespan variation is mainly determined by environmental factors, whereas the
genetic contribution is 25–30% and expected to be polygenic. Two complementary fields go …

In this study we explored the association between aging-related phenotypes previously
reported to predict survival in old age and variation in 77 genes from the DNA repair …

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …