A large part of the aging phenotype, including immunosenescence, is explained by an
imbalance between inflammatory and anti-inflammatory networks, which results in the low …

'Inflammaging'refers to the chronic, low-grade inflammation that characterizes aging. The
conceptualization of inflammaging, resulting from the convergence of studies on the …

In this paper we extend the “network theory of aging,” and we argue that a global reduction
in the capacity to cope with a variety of stressors and a concomitant progressive increase in …

Longevity and aging are two sides of the same coin, as they both derive from the interaction
between genetic and environmental factors. Aging is a complex, dynamic biological process …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Aging, and especially human aging, can be explained by the emerging concept of
parainflammation-driven inflammaging, ie a combination of inflammation and aging …

Both the innate and adaptive immune systems decline with age, causing greater
susceptibility to infectious diseases and reduced responses to vaccination. Diseases are …

The low-grade, chronic, systemic inflammatory state that characterizes the aging process
(inflammaging) results from late evolutive-based expression of the innate immune system …

The process of maintaining life for the individual is a constant struggle to preserve his/her
integrity. This can come at a price when immunity is involved, namely systemic inflammation …

Aging is accompanied by a decline in physiological integrity and a loss of regenerative
capacity in many tissues. The development of interventions that prevent or reverse age …