Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Recent discoveries are redefining our view of cellular senescence as a trigger of tissue
remodelling that acts during normal embryonic development and upon tissue damage. To …

Recent scientific studies have advanced the notion of chronic inflammation as a major risk
factor underlying aging and age-related diseases. In this review, low-grade, unresolved …

Simple Summary Senescence is a form of cell cycle arrest induced by stresses such as DNA
damage and oncogenes and therefore constitutes a crucial barrier against cancer …

SnapShot: Cellular Senescence Pathways Page 1 See online version for legends and
references 816 Cell 170, August 10, 2017 © 2017 Elsevier Inc. DOI http://dx.doi.org/10.1016/j.cell.2017.07.049 …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Aging is an inevitable outcome of life, characterized by a progressive decline in tissue and
organ function. At a molecular level, it is marked by the gradual alterations of biomolecules …

Ageing is driven by the inexorable and stochastic accumulation of damage in biomolecules
vital for proper cellular function. Although this process is fundamentally haphazard and …

Low-grade chronic inflammation is a common denominator in atherogenesis and related
diseases. Solid evidence supports the occurrence of an impairment in the innate and …