In response to persistent DNA damage, induction into cell senescence promotes an
immunogenic program which facilitates immune clearance of these damaged cells. Under …

Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

Nowadays, people are living much longer than they used to do, however they are not free
from ageing. Ageing, an inexorable intrinsic process that affects all cells, tissues, organs and …

Aging is a physiological decline in both structural homeostasis and functional integrity,
progressively affecting organismal health. A major hallmark of aging is the accumulation of …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Life expectancy has increased substantially over the last few decades, leading to a
worldwide increase in the prevalence and burden of aging-associated diseases. Recent …

Understanding the aging process and ways to manipulate it is of major importance for
biology and medicine. Among the many aging theories advanced over the years, the …

The signaling networks that drive the aging process, associated functional deterioration, and
pathologies has captured the scientific community's attention for decades. While many …

Cellular senescence is a highly stable cell cycle arrest that is elicited in response to different
stresses. By imposing a growth arrest, senescence limits the replication of old or damaged …

Cellular senescence as the state of permanent inhibition of cell proliferation is a tumour-
suppressive mechanism. However, due to the associated secretory phenotype senescence …