During embryonic brain development, neural progenitor/stem cells (NPCs) sequentially give
rise to different subtypes of neurons and glia via a highly orchestrated process. To …

The nervous system consists of several hundred neuronal subtypes and glial cells that show
specific gene expression and are generated from common ancestors, neural stem cells …

Neural stem/progenitor cell (NSPC) self-renewal and differentiation in the developing and
the adult brain are controlled by extra-cellular signals and by the inherent competence of …

Neural stem cells (NSCs) have the ability to self-renew and give rise to neurons and glial
cells (astrocytes and oligodendrocytes) in the mammalian central nervous system. This …

Unraveling the mechanisms by which neural stem cells generate distinct cell types remains
a central challenge in central nervous system (CNS) biology. Recent studies have shown …

The generation of neocortical neurons from neural progenitor cells (NPCs) is primarily
controlled by transcription factors binding to DNA in the context of chromatin. To understand …

The process of neurogenesis includes neural stem cell proliferation, fate specification,
young neuron migration, neuronal maturation, and functional integration into existing …

In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …

Epigenetic changes occur throughout life from embryonic development into adulthood. This
results in the timely expression of developmentally important genes, determining the …

The coordinated development of the nervous system requires fidelity in the expression of
specific genes determining the different neural cell phenotypes. Stem cell fate decisions …