Drosophila has long been a successful model organism in multiple biomedical fields. Spatial
gene expression patterns are critical for the understanding of complex pathways and …

Discovery of temporal and spatial patterns of gene expression is essential for understanding
the regulatory networks and development in multicellular organisms. We analyzed the …

By the onset of morphogenesis, Drosophila embryos consist of about 6000 cells that express
distinct gene combinations. Here, we used single-cell sequencing of precisely staged …

Background To model and thoroughly understand animal transcription networks, it is
essential to derive accurate spatial and temporal descriptions of developing gene …

Drosophila melanogaster is a powerful, long-standing model for metazoan development and
gene regulation. We profiled chromatin accessibility in almost 1 million and gene expression …

Background To accurately describe gene expression and computationally model animal
transcriptional networks, it is essential to determine the changing locations of cells in …

Background Cell and tissue specific gene expression is a defining feature of embryonic
development in multi-cellular organisms. However, the range of gene expression patterns …

Background Cell-fate specification and tissue differentiation during development are largely
achieved by the regulation of gene transcription. Results As a first step to creating a …

Molecular profiles of neurons influence neural development and function but bridging the
gap between genes, circuits, and behavior has been very difficult. Here we used single cell …

Background Site-specific transcription factors (TFs) bind DNA regulatory elements to control
expression of target genes, forming the core of gene regulatory networks. Despite decades …