Transformation and transactivation suppressor activity of the c-Jun leucine zipper fused to a bacterial repressor.

M Granger-Schnarr, E Benusiglio… - Proceedings of the …, 1992 - National Acad Sciences
Transcription factor c-Jun appears to be a nuclear target of the Ras-induced signal
transduction pathway. In fact, some experiments show that transforming forms of the Ras …

Suppression of oncogene-induced transformation by a deletion mutant of c-jun.

PH Brown, R Alani, LH Preis, E Szabo, MJ Birrer - Oncogene, 1993 - europepmc.org
Jun and Fos proteins are DNA-binding proteins that are involved in the control of gene
expression through transcriptional regulation. We have made a deletion mutant of the c-jun …

The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells

R Alani, P Brown, B Binétruy, H Dosaka… - … and cellular biology, 1991 - Taylor & Francis
The nuclear phosphoprotein c-Jun, encoded by the proto-oncogene c-jun, is a major
component of the AP-1 complex. A potent transcriptional regulator, c-jun is also able to …

Transformation suppressor activity of a Jun transcription factor lacking its activation domain

A Lloyd, N Yancheva, B Wasylyk - Nature, 1991 - nature.com
THE oncoprotein c-Jun is thought to be a mediator of ras transformation as both its synthesis
and activity as a transcription factor are stimulated by ras expression1, 2. But c-Jun co …

Mechanism of action of a dominant-negative mutant of c-Jun.

PH Brown, TK Chen, MJ Birrer - Oncogene, 1994 - europepmc.org
The AP-1 transcriptional activating complex, made up of Jun and Fos protein, is involved in
controlling many cellular processes such as cell proliferation, differentiation and …

Biochemical analysis of transcriptional activation by Jun: differential activity of c-and v-Jun

D Bohmann, R Tjian - Cell, 1989 - cell.com
The human proto-oncogene product, cJun, is a member of the AP-1 family of transcription
factors, which mediate the regulation of gene expression in response to extracellular …

Activation of c-Jun transcription factor by substitution of a charged residue in its N-terminal domain

WK Hoeffler, AD Levinson, EA Bauer - Nucleic acids research, 1994 - academic.oup.com
C-Jun is a cellular transcription factor that can control gene expression in response to
treatment of cells with phorbol esters, growth factors, and expression of some oncogenes …

Increased transforming activity of JunB and JunD by introduction of an heterologous homodimerization domain.

L Vandel, CM Pfarr, S Huguier, L Loiseau, A Sergeant… - Oncogene, 1995 - europepmc.org
The closely-related proteins c-Jun, JunB and JunD form a family of transcription factors
which require dimerization for DNA-binding and transcriptional activity. Dimerization is …

Epidermal growth factor induction of the c-jun promoter by a Rac pathway

N Clarke, N Arenzana, T Hai, A Minden… - Molecular and cellular …, 1998 - Am Soc Microbiol
The c-jun proto-oncogene encodes a transcription factor which is activated by mitogens both
transcriptionally and by phosphorylation by Jun N-terminal kinase (JNK). We have …

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.

JK Westwick, AD Cox, CJ Der… - Proceedings of the …, 1994 - National Acad Sciences
c-Jun transcriptional activity is augmented by expression of oncogenic Ras and Raf proteins.
This study demonstrates a direct correlation between Ras transforming activity and c-Jun …