Epigenetic mechanisms regulating COVID-19 infection

S Chlamydas, AG Papavassiliou, C Piperi - Epigenetics, 2021 - Taylor & Francis
ABSTRACT Coronavirus disease 2019 (COVID-2019) outbreak originating in December
2019 in Wuhan, China has emerged as a global threat to human health. The highly …

Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis

C Lorente-Sorolla, A Garcia-Gomez, F Català-Moll… - Genome medicine, 2019 - Springer
Background Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic
immune response to infection, associates with reduced responsiveness to subsequent …

Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization

Y Bejaoui, F Humaira Amanullah, M Saad, S Taleb… - Clinical …, 2023 - Springer
Background Aging has been reported as a major risk factor for severe symptoms and higher
mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and …

Deciphering epigenetic (s) role in modulating susceptibility to and severity of COVID-19 infection and/or outcome: a systematic rapid review

SG AbdelHamid, AA Refaat, AM Benjamin… - … Science and Pollution …, 2021 - Springer
COVID-19 pandemic waves hitting worldwide result in drastic postinfection complications
with interindividual variations, which raised the question for the cause of these observed …

[HTML][HTML] Maternal SARS-CoV-2 exposure alters infant DNA methylation

RA Hill, A Gibbons, U Han, W Suwakulsiri… - Brain, Behavior, & …, 2023 - Elsevier
Background Infection during pregnancy can increase the risk of neurodevelopmental
disorders in offspring. The impact of maternal SARS-CoV-2 infection on infant …

DNA Methylation variability among individuals is related to CpGs cluster density and evolutionary signatures

D Palumbo, O Affinito, A Monticelli, S Cocozza - BMC genomics, 2018 - Springer
Background In recent years, epigenetics has gained a central role in the understanding of
the process of natural selection. It is now clear how environmental impacts on the …

[HTML][HTML] Cell-free DNA maps COVID-19 tissue injury and risk of death and can cause tissue injury

TE Andargie, N Tsuji, F Seifuddin, MK Jang, PST Yuen… - JCI insight, 2021 - ncbi.nlm.nih.gov
METHODS We conducted a multicenter prospective cohort study to enroll patients with
COVID-19 and collect plasma samples. Plasma cfDNA was subject to bisulfite sequencing …

Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion

NS Giroux, S Ding, MT McClain, TW Burke, E Petzold… - Scientific reports, 2022 - nature.com
SARS-CoV-2 infection triggers profound and variable immune responses in human hosts.
Chromatin remodeling has been observed in individuals severely ill or convalescing with …

Global m6A RNA methylation in SARS-CoV-2 positive nasopharyngeal samples in a Mexican population: a first approximation study

JL Batista-Roche, B Gómez-Gil, G Lund… - Epigenomes, 2022 - mdpi.com
The Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is the causal agent
of COVID-19 (Coronavirus Disease-19). Both mutation and/or recombination events in the …

Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals

X Zhang, AC Justice, Y Hu, Z Wang, H Zhao, G Wang… - Epigenetics, 2016 - Taylor & Francis
Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …