Aim: Peripheral blood monocytes (PBMs) play multiple and critical roles in the immune
response, and abnormalities in PBMs have been linked to a variety of human disorders …

T cells play a critical role in coronavirus diseases. How they do so in COVID-19 may be
revealed by analyzing the epigenetic chromatin accessibility of cis-and trans-regulatory …

Severe acute respiratory syndrome coronavirus-2 is a positive-sense RNA virus, a causal
agent of ongoing COVID-19 pandemic. ACE2R methylation across three CpG sites …

Age-related variations in DNA methylation have been reported; however, the functional
relevance of these differentially methylated sites (age-dMS) are unclear. Here we report …

Cytosine methylation at CpG dinucleotides is an epigenetic mechanism that affects the gene
expression profiles responsible for the functional differences in various cells and tissues …

Patients infected with SARS-CoV-2 at various severities have different clinical
manifestations and treatments. Mild or moderate patients usually recover with conventional …

Human ageing affects the immune system resulting in an overall decline in
immunocompetence. Although all immune cells are affected during aging, the functional …

DNA methylation is an epigenetic mark thought to be robust to environmental perturbations
on a short time scale. Here, we challenge that view by demonstrating that the infection of …

We report the in vitro antiviral activity of DZNep (3-Deazaneplanocin A; an inhibitor of S-
adenosylmethionine-dependent methyltransferase) against SARS-CoV-2, besides …

Background Ageing affects many components of the immune system, including innate
immune cells like monocytes. They are important in the early response to pathogens and for …