Epigenome-wide profiling identifies significant differences in DNA methylation between matched-pairs of T-and B-lymphocytes from healthy individuals
JR Glossop, NB Nixon, RD Emes, KE Haworth… - Epigenetics, 2013 - Taylor & Francis
Multiple reports now describe changes to the DNA methylome in rheumatoid arthritis and in
many cases have analyzed methylation in mixed cell populations from whole blood …
many cases have analyzed methylation in mixed cell populations from whole blood …
[HTML][HTML] m6A Regulator-Mediated Methylation Modification Patterns and Characteristics of Immunity in Blood Leukocytes of COVID-19 Patients
X Qiu, X Hua, Q Li, Q Zhou, J Chen - Frontiers in immunology, 2021 - frontiersin.org
Both RNA N6-methyladenosine (m6A) modification of SARS-CoV-2 and immune
characteristics of the human body have been reported to play an important role in COVID …
characteristics of the human body have been reported to play an important role in COVID …
[HTML][HTML] Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape
K Day, LL Waite, A Thalacker-Mercer, A West… - Genome biology, 2013 - Springer
Background DNA methylation is an epigenetic modification that changes with age in human
tissues, although the mechanisms and specificity of this process are still poorly understood …
tissues, although the mechanisms and specificity of this process are still poorly understood …
[HTML][HTML] DNA methylation in whole blood: uses and challenges
EA Houseman, S Kim, KT Kelsey… - Current environmental …, 2015 - Springer
Due to its convenience, the blood is commonly used in epigenomic studies, but its
heterogeneous nature leads to interpretation difficulties, given the now widely recognized …
heterogeneous nature leads to interpretation difficulties, given the now widely recognized …
[HTML][HTML] Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
DL McCartney, JL Min, RC Richmond, AT Lu… - Genome biology, 2021 - Springer
Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …
and correlate with morbidity and mortality. Consequently, identification of genetic and …
Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites
I Florath, K Butterbach, H Müller… - Human molecular …, 2014 - academic.oup.com
Understanding the role of epigenetic modifications, eg DNA methylation, in the process of
aging requires the characterization of methylation patterns in large cohorts. We analysed> …
aging requires the characterization of methylation patterns in large cohorts. We analysed> …
Alterations in DNA methylation status associated with gulf war illness
MS Trivedi, MM Abreu, L Sarria, N Rose… - DNA and Cell …, 2019 - liebertpub.com
Gulf War Illness (GWI) affects about 25% of Persian Gulf veterans with a cluster of chronic
symptoms, including immune dysfunction and neurological issues. Recent studies implicate …
symptoms, including immune dysfunction and neurological issues. Recent studies implicate …
[HTML][HTML] Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality
Background The effects of tobacco smoking on epigenome-wide methylation signatures in
white blood cells (WBCs) collected from persons living with HIV may have important …
white blood cells (WBCs) collected from persons living with HIV may have important …
[HTML][HTML] Unraveling risk genes of COVID-19 by multi-omics integrative analyses
A Baranova, H Cao, F Zhang - Frontiers in Medicine, 2021 - frontiersin.org
Objectives: Uncovering the genetic basis of COVID-19 may shed insight into its
pathogenesis and help to improve treatment measures. We aimed to investigate the host …
pathogenesis and help to improve treatment measures. We aimed to investigate the host …
[HTML][HTML] A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
Here we examine the association between DNA methylation in circulating leukocytes and
blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel …
blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel …