Postmitotic neurons are subject to a vast array of environmental influences that require the
nuclear integration of intracellular signaling events to promote a wide variety of neuroplastic …

In recent years spectacular advances in the field of epigenetics have taken place. Multiple
lines of evidence that connect epigenetic regulation to brain functions have been …

Highlights•Histone modifications are highly dynamic in the brain and drive changes in many
behaviors including learning and memory.•Chromatin-associated proteins that interact with …

Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Epigenetic changes are commonly considered stable modifications of the chromatin that
define the differentiation state of cells during the development. Within the central nervous …

Neurons are dynamic cells that respond and adapt to stimuli throughout their long
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

Chromatin structure is an essential regulator of gene expression. Its state of compaction
contributes to the regulation of genetic programs, in particular during differentiation …

Neural stem cells generate distinct cell types for tissue formation and cell replacement
during development and throughout adulthood. Neural development and plasticity are …

Epigenetic regulation has been long considered to be a critical mechanism in the control of
key aspects of cellular functions such as cell division, growth, and cell fate determination …