TLRs: innate immune sentries against SARS-CoV-2 infection

S Mantovani, B Oliviero, S Varchetta, A Renieri… - International Journal of …, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March …

Toll-like receptors (TLRs) as therapeutic targets for treating SARS-CoV-2: An immunobiological perspective

R Patra, NC Das, S Mukherjee - … –Volume I: Basic Science and Therapy …, 2022 - Springer
Abstract Introduction: Coronavirus disease-19 (COVID-19) caused by SARS-CoV-2 is
presently the biggest threat to mankind throughout the globe. Increasing reports on deaths …

Toll-like receptor mediation in SARS-CoV-2: a therapeutic approach

A Manan, RH Pirzada, M Haseeb, S Choi - International journal of …, 2022 - mdpi.com
The innate immune system facilitates defense mechanisms against pathogen invasion and
cell damage. Toll-like receptors (TLRs) assist in the activation of the innate immune system …

Role of Toll‐like receptors in the pathogenesis of COVID‐19

S Khanmohammadi, N Rezaei - Journal of medical virology, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), has led to a pandemic since March 2020. The …

Toll-like receptor (TLRs) agonists and antagonists for COVID-19 treatments

ZM Liu, MH Yang, K Yu, ZX Lian… - Frontiers in Pharmacology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) rapidly infects
humans and animals which make coronavirus disease 2019 (COVID-19) a grievous …

Association of TLR3 functional variant (rs3775291) with COVID-19 susceptibility and death: a population-scale study

G Dhangadamajhi, R Rout - Human cell, 2021 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the recent
pandemic of coronavirus disease-19 (COVID-19) has a long, positive-sense, non …

Toll-like receptor signaling in severe acute respiratory syndrome coronavirus 2-induced innate immune responses and the potential application value of toll-like …

J Dai, Y Wang, H Wang, Z Gao, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Toll-like receptors (TLRs) are key sensors that recognize the pathogen-associated
molecular patterns (PAMPs) of severe acute respiratory syndrome coronavirus 2 (SARS …

Innate receptor activation patterns involving TLR and NLR synergisms in COVID-19, ALI/ARDS and sepsis cytokine storms: a review and model making novel …

R Root-Bernstein - International journal of molecular sciences, 2021 - mdpi.com
Severe COVID-19 is characterized by a “cytokine storm”, the mechanism of which is not yet
understood. I propose that cytokine storms result from synergistic interactions among Toll …

In silico analyses on the comparative sensing of SARS‐CoV‐2 mRNA by the intracellular TLRs of humans

A Choudhury, NC Das, R Patra… - Journal of Medical …, 2021 - Wiley Online Library
Abstract The coronavirus disease‐2019 (COVID‐19) pandemic caused by severe acute
respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has already resulted in a huge setback …

Current understanding of the innate control of toll-like receptors in response to SARS-CoV-2 infection

HE Jung, HK Lee - Viruses, 2021 - mdpi.com
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, threatens the entire world. It …