[HTML][HTML] Aging: a common driver of chronic diseases and a target for novel interventions

BK Kennedy, SL Berger, A Brunet, J Campisi… - Cell, 2014 - ncbi.nlm.nih.gov
Mammalian aging can be delayed with genetic, dietary and pharmacologic approaches.
Given that the elderly population is dramatically increasing and that aging is the greatest risk …

[HTML][HTML] Geroscience: linking aging to chronic disease

BK Kennedy, SL Berger, A Brunet, J Campisi… - Cell, 2014 - cell.com
Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches.
Given that the elderly population is dramatically increasing and that aging is the greatest risk …

Healthy aging: the ultimate preventative medicine

M Kaeberlein, PS Rabinovitch, GM Martin - Science, 2015 - science.org
Age is the greatest risk factor for nearly every major cause of mortality in developed nations.
Despite this, most biomedical research focuses on individual disease processes without …

Extending human healthspan and longevity: a symposium report

LM DeVito, N Barzilai, AM Cuervo… - Annals of the New …, 2022 - Wiley Online Library
For many years, it was believed that the aging process was inevitable and that age‐related
diseases could not be prevented or reversed. The geroscience hypothesis, however, posits …

Can we delay aging? The biology and science of aging

B Anton, L Vitetta, F Cortizo… - Annals of the New York …, 2005 - Wiley Online Library
Long before the fountain of youth, mankind has had an interest in staying young. As we
move into the 21st century, that interest has not only continued, but it has become an …

Intervening in ageing to prevent the diseases of ageing

L Partridge - Trends in Endocrinology & Metabolism, 2014 - cell.com
Increases in human lifespan worldwide have revealed that advancing age is the
predominant risk factor for major life-threatening diseases. Recent work has shown that …

[HTML][HTML] Aging and age‐related diseases: from mechanisms to therapeutic strategies

Z Li, Z Zhang, Y Ren, Y Wang, J Fang, H Yue, S Ma… - Biogerontology, 2021 - Springer
Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

Aging as a biological target for prevention and therapy

N Barzilai, AM Cuervo, S Austad - Jama, 2018 - jamanetwork.com
Chronic health problems related to the unprecedented aging of the human population in the
21st century threaten to disrupt economies and degrade the quality of later life throughout …

The geroscience hypothesis: is it possible to change the rate of aging?

SN Austad - Advances in geroscience, 2016 - Springer
Aging is not a disease. It is a generalized and progressive loss of function with the passage
of time that makes us increasingly vulnerable to a broad suite of diseases. The Geroscience …

[HTML][HTML] Translational geroscience: emphasizing function to achieve optimal longevity

DR Seals, S Melov - Aging (albany NY), 2014 - ncbi.nlm.nih.gov
Among individuals, biological aging leads to cellular and organismal dysfunction and an
increased risk of chronic degenerative diseases and disability. This sequence of events in …