Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Much of the current research on longevity focuses on the aging process within a single
species. Several molecular players (eg IGF1 and MTOR), pharmacological compounds (eg …

Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative
transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with …

Aging is a global decline of physiological functions, leading to an increased susceptibility to
diseases and ultimately death. Maximum lifespans differ up to 200-fold between mammalian …

Several pharmacological, dietary, and genetic interventions that increase mammalian
lifespan are known, but general principles of lifespan extension remain unclear. Here, we …

Research on longevity and healthy aging promises to increase our lifespan and decrease
the burden of degenerative diseases with important social and economic effects. Many …

Ample evidence from model organisms has indicated that subtle variation in genes can
dramatically influence lifespan. The key genes and molecular pathways that have been …

Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …

Current concepts regarding the biology of aging are primarily based on studies aimed at
identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging …

Here we review the examples of great longevity and potential immortality in the earliest
animal types and contrast and compare these to humans and other higher animals. We start …