Impaired folate-mediated 1-carbon metabolism has been linked to multiple disease
outcomes. A better understanding of the nutritional and genetic influences on this complex …

Impairments in folate-mediated 1-carbon metabolism are associated with several common
diseases and developmental anomalies including intestinal cancers, vascular disease …

The B-vitamin folate is essential for one-carbon transfer reactions. These include
methylation reactions, such as the methylation of DNA or other substrates (by use of S …

Background: Previous mathematical models for hepatic and tissue one-carbon metabolism
have been combined and extended to include a blood plasma compartment. We use this …

Folate is an essential nutrient that is involved in many metabolic pathways, including amino
acid interconversions and nucleotide (DNA) synthesis. In genetically susceptible individuals …

Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways
necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of …

Tetrahydrofolate (THF) polyglutamates are a family of cofactors that carry and chemically
activate one‐carbon units for biosynthesis. THF‐mediated one‐carbon metabolism is a …

A common genetic polymorphism results from a C→ T substitution in the gene encoding
methylenetetrahydrofolate reductase (MTHFR), the enzyme that produces 5 …

The vitamin folate functions within the cell as a carrier of one-carbon units. The requirement
for one-carbon transfers is ubiquitous and all mammalian cells carry out folate dependent …

Scope Folate status and the status of the methionine cycle are typically assessed by
measuring folate and metabolites in the plasma. It is assumed that plasma metabolite levels …