Single-cell RNA-seq (scRNA-seq) studies have profiled over 100 million human cells across
diseases, developmental stages, and perturbations to date. A singular view of this vast and …

Abstract single-cell sequencing methods have enabled the profiling of multiple types of
molecular readouts at cellular resolution, and recent developments in spatial barcoding, in …

Recent advances in single-cell technologies are providing exciting opportunities for
dissecting tissue heterogeneity and investigating cell identity, fate and function. This is a …

Cells require coordinated control over gene expression when responding to environmental
stimuli. Here we apply scATAC-seq and single-cell RNA sequencing (scRNA-seq) in resting …

With the rapid advance of single-cell sequencing technology, cell heterogeneity in various
biological processes was dissected at different omics levels. However, single-cell mono …

Cardiovascular disease is the leading cause of death worldwide. Advanced insights into
disease mechanisms and strategies to improve therapeutic opportunities require deeper …

Single-cell analysis is a rapidly evolving approach to characterize genome-scale molecular
information at the individual cell level. Development of single-cell technologies and …

Cell biology is increasingly focused on cellular heterogeneity and multicellular systems. To
make the fullest use of experimental, clinical, and computational efforts, we need …

The cell is the fundamental constituent unit of a mammal which, in turn, depends on the
cooperative work of various cells to compose intricate life activities. Cells harbor diverse …

The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …