[HTML][HTML] SARS-CoV-2 achieves immune escape by destroying mitochondrial quality: comprehensive analysis of the cellular landscapes of lung and blood specimens …

C Duan, R Ma, X Zeng, B Chen, D Hou, R Liu… - Frontiers in …, 2022 - frontiersin.org
Mitochondria get caught in the crossfire of coronavirus disease 2019 (COVID-19) and
antiviral immunity. The mitochondria-mediated antiviral immunity represents the host's first …

[HTML][HTML] SARS-CoV-2 causes mitochondrial dysfunction and mitophagy impairment

C Shang, Z Liu, Y Zhu, J Lu, C Ge, C Zhang… - Frontiers in …, 2022 - frontiersin.org
Mitochondria, which is essential for adequate innate immune response, energy metabolism
and mitochondria reactive oxygen species (ROS) production, might be in the cross fire of …

[HTML][HTML] Immune system cells from COVID-19 patients display compromised mitochondrial-nuclear expression co-regulation and rewiring toward glycolysis

H Medini, A Zirman, D Mishmar - Iscience, 2021 - cell.com
Mitochondria are pivotal for bioenergetics, as well as in cellular response to viral infections.
Nevertheless, their role in COVID-19 was largely overlooked. Here, we analyzed available …

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts

JW Guarnieri, JM Dybas, H Fazelinia, MS Kim… - Science translational …, 2023 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …

[HTML][HTML] SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia

SL Archer, A Dasgupta, KH Chen, D Wu, K Baid… - Redox Biology, 2022 - Elsevier
Rationale Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-
19 pneumonia. We hypothesize that SARS-CoV-2 causes alveolar injury and hypoxemia by …

[HTML][HTML] Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

B Miller, A Silverstein, M Flores, K Cao, H Kumagai… - Scientific Reports, 2021 - nature.com
SARS-CoV-2 induces a muted innate immune response compared to other respiratory
viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate …

[HTML][HTML] Host mitochondria: more than an organelle in SARS-CoV-2 infection

S Shoraka, AE Samarasinghe, A Ghaemi… - Frontiers in Cellular …, 2023 - frontiersin.org
Since December 2019, the world has been facing viral pandemic called COVID-19
(Coronavirus disease 2019) caused by a new beta-coronavirus named severe acute …

[HTML][HTML] Roles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?

K Srinivasan, AK Pandey, A Livingston… - Molecular …, 2021 - Springer
The recent emergence of severe acute respiratory syndrome-Corona Virus 2 (SARS-CoV-2)
in late 2019 and its spread worldwide caused an acute pandemic of Coronavirus disease 19 …

Mitochondria and microbiota dysfunction in COVID-19 pathogenesis

J Saleh, C Peyssonnaux, KK Singh, M Edeas - Mitochondrion, 2020 - Elsevier
The COVID-19 pandemic caused by the coronavirus (SARS-CoV-2) has taken the world by
surprise into a major crisis of overwhelming morbidity and mortality. This highly infectious …

Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis

KK Singh, G Chaubey, JY Chen… - American Journal of …, 2020 - journals.physiology.org
Because of the ongoing pandemic around the world, the mechanisms underlying the SARS-
CoV-2-induced COVID-19 are subject to intense investigation. Based on available data for …