[HTML][HTML] Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infection

J Bińkowski, O Taryma-Leśniak, K Łuczkowska… - Biomedicine & …, 2022 - Elsevier
Recent studies have shown that methylation changes identified in blood cells of COVID-19
patients have a potential to be used as biomarkers of SARS-CoV-2 infection outcomes …

Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19

MJ Corley, APS Pang, K Dody, PA Mudd… - Journal of leukocyte …, 2021 - academic.oup.com
The global pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is a highly pathogenic RNA virus causing coronavirus disease 2019 (COVID …

[HTML][HTML] Host methylation predicts SARS-CoV-2 infection and clinical outcome

IR Konigsberg, B Barnes, M Campbell… - Communications …, 2021 - nature.com
Background Since the onset of the SARS-CoV-2 pandemic, most clinical testing has focused
on RT-PCR. Host epigenome manipulation post coronavirus infection,–suggests that DNA …

[HTML][HTML] DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome

M Bradic, S Taleb, B Thomas, O Chidiac… - Journal of Translational …, 2022 - Springer
Background COVID-19 infections could be complicated by acute respiratory distress
syndrome (ARDS), increasing mortality risk. We sought to assess the methylome of …

[HTML][HTML] Epigenome-wide DNA methylation profiling of healthy COVID-19 recoverees reveals a unique signature in circulating immune cells

J Huoman, S Sayyab, E Apostolou, L Karlsson… - 2021 - europepmc.org
Background Epigenetic alterations upon microbial challenge have been described as both a
defence strategy and a result of pathogenic manipulation. While most COVID-19 studies …

[HTML][HTML] Identification of whole-blood DNA methylation signatures and rules associated with COVID-19 severity

F Yuan, JX Ren, HP Liao, W Guo, L Chen… - Frontiers in Bioscience …, 2023 - imrpress.com
Background: Different severities of coronavirus disease 2019 (COVID-19) cause different
levels of respiratory symptoms and systemic inflammation. DNA methylation, a heritable …

[HTML][HTML] Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection

G Barturen, E Carnero-Montoro… - Nature …, 2022 - nature.com
SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many
cases, to bilateral pneumonia, severe dyspnea, and in~ 5% of these, death. DNA …

[HTML][HTML] Identification of COVID-19-associated DNA methylation variations by integrating methylation array and scRNA-Seq data at cell-type resolution

G Wang, Z Xiong, F Yang, X Zheng, W Zong, R Li… - Genes, 2022 - mdpi.com
Single-cell transcriptome studies have revealed immune dysfunction in COVID-19 patients,
including lymphopenia, T cell exhaustion, and increased levels of pro-inflammatory …

[HTML][HTML] Longitudinal study of DNA methylation and epigenetic clocks prior to and following test-confirmed COVID-19 and mRNA vaccination

APS Pang, AT Higgins-Chen, F Comite, I Raica… - Frontiers in …, 2022 - frontiersin.org
The host epigenetic landscape rapidly changes during SARS-CoV-2 infection, and evidence
suggest that severe COVID-19 is associated with durable scars to the epigenome …

[HTML][HTML] Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of …

G Godoy-Tena, A Barmada, O Morante-Palacios… - Genome Medicine, 2022 - Springer
Background COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from
asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are …