Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to
changes in the underlying DNA sequence, most notably chromatin remodeling driven by …

Aging, which is accompanied by decreased organ function and increased disease
incidence, limits human lifespan and has attracted investigators for thousands of years. In …

Aging is the most important risk factor for major human lifestyle diseases, including cancer,
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …

Aging is a complex process that results in compromised biological functions of the organism
and increased susceptibility to disease and death. Although the molecular basis of aging is …

A global DNA hypomethylation and local changes in the methylation levels of specific DNA
loci occur during aging in mammals. Global hypomethylation mainly affects highly …

Aging is characterized by functional decline of diverse organs and an increased risk for
several diseases. Therefore, a high interest exists in understanding the molecular …