In our study, whole‐genome methylation arrays were applied to identify novel genes with
tumor specific DNA methylation of promoter CpG islands in pre‐malignant and malignant …

An abnormal pattern of DNA methylation occurs at specific genes in almost all neoplasms.
The lack of high-throughput methods with high specificity and sensitivity to detect changes in …

CpG island hypermethylation is a potential means of inactivating tumor suppressor genes,
and many genes have been demonstrated to be hypermethylated and silenced in colorectal …

Background Tumor cell lines are commonly used as experimental tools in cancer research,
but their relevance for the in vivo situation is debated. In a series of 11 microsatellite stable …

We have developed a transcriptome-wide approach to identify genes affected by promoter
CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By …

Transcriptional silencing by CpG island hypermethylation is a potential mechanism for the
inactivation of tumor-related genes. Virtually, all types of human cancers show CpG island …

Background Aberrant DNA methylation profiles are a characteristic of all known cancer
types, epitomized by the CpG island methylator phenotype (CIMP) in colorectal cancer …

Abstract Background and Aims: CpG island methylation is present in various tumors,
including colorectal carcinomas, and is thought to be an important mechanism in …

We provide a comprehensive description of our microarray-based technique for the
simultaneous detection of multiple CpG islands in cancer. Amplicons from tumor and control …

Hypermethylation of cytosine residues in the CpG islands of tumor suppressor genes is a
key mechanism of colorectal carcinogenesis. Detection and quantification of CpG island …