The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2

RD Chow, M Majety, S Chen - Nature Communications, 2021 - nature.com
Age is a major risk factor for severe coronavirus disease-2019 (COVID-19). Here, we
interrogate the transcriptional features and cellular landscape of the aging human lung. By …

The COVID-19 pandemic: does our early life environment, life trajectory and socioeconomic status determine disease susceptibility and severity?

C Holuka, MP Merz, SB Fernandes… - International journal of …, 2020 - mdpi.com
A poor socioeconomic environment and social adversity are fundamental determinants of
human life span, well-being and health. Previous influenza pandemics showed that …

A methylation clock model of mild SARS‐CoV‐2 infection provides insight into immune dysregulation

W Mao, CM Miller, VD Nair, Y Ge… - Molecular Systems …, 2023 - embopress.org
DNA methylation comprises a cumulative record of lifetime exposures superimposed on
genetically determined markers. Little is known about methylation dynamics in humans …

[HTML][HTML] Shorter telomere lengths in patients with severe COVID-19 disease

R Sanchez-Vazquez, A Guío-Carrión… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
The incidence of severe manifestations of COVID-19 increases with age with older patients
showing the highest mortality, suggesting that molecular pathways underlying aging …

HIV-1 infection accelerates age according to the epigenetic clock

S Horvath, AJ Levine - The Journal of infectious diseases, 2015 - academic.oup.com
Background. Infection with human immunodeficiency virus type 1 (HIV) is associated with
clinical symptoms of accelerated aging, as evidenced by the increased incidence and …

Blood DNA methylation and COVID-19 outcomes

J Balnis, A Madrid, KJ Hogan, LA Drake, HC Chieng… - Clinical …, 2021 - Springer
Background There are no prior reports that compare differentially methylated regions of DNA
in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 …

[HTML][HTML] SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime

R Domingues, A Lippi, C Setz, TF Outeiro… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Pneumonia outbreak in the city of Wuhan, China, prompted the finding of a novel strain of
severe acute respiratory syndrome virus (SARS-CoV-2). Here, we discuss potential long …

DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging

S Sepe, F Rossiello, V Cancila, F Iannelli, V Matti… - EMBO …, 2022 - embopress.org
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes the
coronavirus disease 2019 (COVID‐19), known to be more common in the elderly, who also …

[HTML][HTML] Role of senescence in the chronic health consequences of COVID-19

EOW Gerdes, G Vanichkachorn, BP Verdoorn… - Translational …, 2022 - Elsevier
While the full impact of COVID-19 is not yet clear, early studies have indicated that upwards
of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long …

Role of senescence and aging in SARS-CoV-2 infection and COVID-19 disease

SM Lynch, G Guo, DS Gibson, AJ Bjourson, TS Rai - Cells, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic associated with substantial …