Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals
T Nevalainen, L Kananen, S Marttila, J Jylhävä… - Clinical …, 2017 - Springer
Background Human aging is associated with profound changes in one of the major
epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …
epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …
SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response
S Tsuji, S Minami, R Hashimoto, Y Konishi, T Suzuki… - Nature aging, 2022 - nature.com
Reports of post-acute COVID-19 syndrome, in which the inflammatory response persists
even after SARS-CoV-2 has disappeared, are increasing, but the underlying mechanisms of …
even after SARS-CoV-2 has disappeared, are increasing, but the underlying mechanisms of …
Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19
C Guo, M Wu, B Huang, R Zhao, L Jin, B Fu, P Wang… - Genome medicine, 2022 - Springer
Background Natural killer (NK) cells are innate lymphoid cells that mediate antitumour and
antiviral responses. However, very little is known about how ageing influences human NK …
antiviral responses. However, very little is known about how ageing influences human NK …
Aging in COVID-19: Vulnerability, immunity and intervention
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic was first
reported in Wuhan, China in December 2019, moved across the globe at an unprecedented …
reported in Wuhan, China in December 2019, moved across the globe at an unprecedented …
Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19
MJ Corley, APS Pang, K Dody, PA Mudd… - Journal of leukocyte …, 2021 - academic.oup.com
The global pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is a highly pathogenic RNA virus causing coronavirus disease 2019 (COVID …
(SARS-CoV-2) is a highly pathogenic RNA virus causing coronavirus disease 2019 (COVID …
Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection
G Barturen, E Carnero-Montoro… - Nature …, 2022 - nature.com
SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many
cases, to bilateral pneumonia, severe dyspnea, and in~ 5% of these, death. DNA …
cases, to bilateral pneumonia, severe dyspnea, and in~ 5% of these, death. DNA …
Cellular senescence: friend or foe to respiratory viral infections?
WJ Kelley, RL Zemans… - European Respiratory …, 2020 - Eur Respiratory Soc
Cellular senescence permanently arrests the replication of various cell types and contributes
to age-associated diseases. In particular, cellular senescence may enhance chronic lung …
to age-associated diseases. In particular, cellular senescence may enhance chronic lung …
The age distribution of mortality from novel coronavirus disease (COVID-19) suggests no large difference of susceptibility by age
Abstract Among Italy, Spain, and Japan, the age distributions of COVID-19 mortality show
only small variation even though the number of deaths per country shows large variation. To …
only small variation even though the number of deaths per country shows large variation. To …
Age-related vulnerability to coronavirus disease 2019 (COVID-19): biological, contextual, and policy-related factors
EM Crimmins - Public Policy & Aging Report, 2020 - academic.oup.com
The detailed facts surrounding the coronavirus disease 2019 (COVID-19) pandemic are still
evolving; however, one of the most shocking aspects of the COVID-19 pandemic is how …
evolving; however, one of the most shocking aspects of the COVID-19 pandemic is how …
An epigenome-wide association study of sex-specific chronological ageing
Background Advanced age is associated with cognitive and physical decline and is a major
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …