[HTML][HTML] Exploiting the molecular basis of age and gender differences in outcomes of SARS-CoV-2 infections
Motivation: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
(coronavirus disease, 2019; COVID-19) is associated with adverse outcomes in patients. It …
(coronavirus disease, 2019; COVID-19) is associated with adverse outcomes in patients. It …
[HTML][HTML] Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
AM Tizazu, HM Mengist, G Demeke - Immunity & Ageing, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused
by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is …
by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is …
Reversing age: dual species measurement of epigenetic age with a single clock
Young blood plasma is known to confer beneficial effects on various organs in mice.
However, it was not known whether young plasma rejuvenates cells and tissues at the …
However, it was not known whether young plasma rejuvenates cells and tissues at the …
[HTML][HTML] Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia
D Lo Tartaro, A Neroni, A Paolini, R Borella… - Communications …, 2022 - nature.com
Aging is a major risk factor for developing severe COVID-19, but few detailed data are
available concerning immunological changes after infection in aged individuals. Here we …
available concerning immunological changes after infection in aged individuals. Here we …
Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring
The role of epigenetics in the modulation of longevity has not been studied in humans. To
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …
this aim,(1) we evaluated the DNA methylation from peripheral leukocytes of 21 female …
[HTML][HTML] GWAS of epigenetic aging rates in blood reveals a critical role for TERT
DNA methylation age is an accurate biomarker of chronological age and predicts lifespan,
but its underlying molecular mechanisms are unknown. In this genome-wide association …
but its underlying molecular mechanisms are unknown. In this genome-wide association …
Tracking the epigenetic clock across the human life course: a meta-analysis of longitudinal cohort data
Background Epigenetic clocks based on DNA methylation yield high correlations with
chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not …
chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not …
Epigenetic mechanisms regulating COVID-19 infection
S Chlamydas, AG Papavassiliou, C Piperi - Epigenetics, 2021 - Taylor & Francis
ABSTRACT Coronavirus disease 2019 (COVID-2019) outbreak originating in December
2019 in Wuhan, China has emerged as a global threat to human health. The highly …
2019 in Wuhan, China has emerged as a global threat to human health. The highly …
[HTML][HTML] Age-dependent assessment of genes involved in cellular senescence, telomere, and mitochondrial pathways in human lung tissue of smokers, COPD, and …
Background Aging is one of the key contributing factors for chronic obstructive pulmonary
diseases (COPD) and other chronic inflammatory lung diseases. Here, we determined how …
diseases (COPD) and other chronic inflammatory lung diseases. Here, we determined how …
Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex
GL Shireby, JP Davies, PT Francis, J Burrage… - Brain, 2020 - academic.oup.com
Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …
as 'epigenetic clocks', which have been widely used to identify differences between …