[HTML][HTML] Simplified assay for epigenetic age estimation in whole blood of adults
L Vidal-Bralo, Y Lopez-Golan, A Gonzalez - Frontiers in genetics, 2016 - frontiersin.org
Biological age is not always concordant with chronological age and the departures are of
interest for understanding how diseases and environmental insults affect tissue function …
interest for understanding how diseases and environmental insults affect tissue function …
[HTML][HTML] I mmunosenescence and inflammaging: risk factors of severe COVID-19 in older people
AJ Pietrobon, FME Teixeira, MN Sato - Frontiers in immunology, 2020 - frontiersin.org
Old individuals are more susceptible to various infections due to immunological changes
that occur during the aging process. These changes named collectively as …
that occur during the aging process. These changes named collectively as …
[HTML][HTML] Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2–induced systemic toxicity
Extrapulmonary manifestations of COVID-19 are associated with a much higher mortality
rate than pulmonary manifestations. However, little is known about the pathogenesis of …
rate than pulmonary manifestations. However, little is known about the pathogenesis of …
[HTML][HTML] Relationship of tobacco smoking and smoking-related DNA methylation with epigenetic age acceleration
X Gao, Y Zhang, LP Breitling, H Brenner - Oncotarget, 2016 - ncbi.nlm.nih.gov
Recent studies have identified biomarkers of chronological age based on DNA methylation
levels. Since active smoking contributes to a wide spectrum of aging-related diseases in …
levels. Since active smoking contributes to a wide spectrum of aging-related diseases in …
[HTML][HTML] Host methylation predicts SARS-CoV-2 infection and clinical outcome
IR Konigsberg, B Barnes, M Campbell… - Communications …, 2021 - nature.com
Background Since the onset of the SARS-CoV-2 pandemic, most clinical testing has focused
on RT-PCR. Host epigenome manipulation post coronavirus infection,–suggests that DNA …
on RT-PCR. Host epigenome manipulation post coronavirus infection,–suggests that DNA …
[HTML][HTML] Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception
Background The well-established association of chronological age with changes in DNA
methylation is primarily founded on the analysis of large sets of blood samples, while …
methylation is primarily founded on the analysis of large sets of blood samples, while …
Universal DNA methylation age across mammalian tissues
Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
[HTML][HTML] Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing
Background DNA methylation changes with age. Chronological age predictors built from
DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the …
DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the …
[HTML][HTML] A pan-tissue DNA-methylation epigenetic clock based on deep learning
Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been
created in recent years, with the vast majority based on regularized linear regression. This …
created in recent years, with the vast majority based on regularized linear regression. This …
Epigenetic clock: DNA methylation in aging
S Jiang, Y Guo - Stem cells international, 2020 - Wiley Online Library
Aging, which is accompanied by decreased organ function and increased disease
incidence, limits human lifespan and has attracted investigators for thousands of years. In …
incidence, limits human lifespan and has attracted investigators for thousands of years. In …