[HTML][HTML] Dysfunctional epigenetic aging of the normal colon and colorectal cancer risk
Background Chronological age is a prominent risk factor for many types of cancers including
colorectal cancer (CRC). Yet, the risk of CRC varies substantially between individuals, even …
colorectal cancer (CRC). Yet, the risk of CRC varies substantially between individuals, even …
[HTML][HTML] DNA methylation age of blood predicts all-cause mortality in later life
Background DNA methylation levels change with age. Recent studies have identified
biomarkers of chronological age based on DNA methylation levels. It is not yet known …
biomarkers of chronological age based on DNA methylation levels. It is not yet known …
Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders
AJ Levine, A Quach, DJ Moore, CL Achim… - Journal of …, 2016 - Springer
HIV infection leads to age-related conditions in relatively young persons. HIV-associated
neurocognitive disorders (HAND) are considered among the most prevalent of these …
neurocognitive disorders (HAND) are considered among the most prevalent of these …
Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Menopause accelerates biological aging
Although epigenetic processes have been linked to aging and disease in other systems, it is
not yet known whether they relate to reproductive aging. Recently, we developed a highly …
not yet known whether they relate to reproductive aging. Recently, we developed a highly …
[HTML][HTML] New targeted approaches for epigenetic age predictions
Background Age-associated DNA methylation changes provide a promising biomarker for
the aging process. While genome-wide DNA methylation profiles enable robust age …
the aging process. While genome-wide DNA methylation profiles enable robust age …
[HTML][HTML] Continuous aging of the human DNA methylome throughout the human lifespan
Å Johansson, S Enroth, U Gyllensten - PloS one, 2013 - journals.plos.org
DNA methylation plays an important role in development of disease and the process of
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …
[HTML][HTML] Human age prediction based on DNA methylation using a gradient boosting regressor
X Li, W Li, Y Xu - Genes, 2018 - mdpi.com
All tissues of organisms will become old as time goes on. In recent years, epigenetic
investigations have found that there is a close correlation between DNA methylation and …
investigations have found that there is a close correlation between DNA methylation and …
[HTML][HTML] Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci
JL Buxton, M Suderman, JJ Pappas, N Borghol… - Scientific reports, 2014 - nature.com
In humans, leukocyte telomere length (LTL) is positively correlated with lifespan and shorter
LTL is associated with increased risk of age-related disease. In this study we tested for …
LTL is associated with increased risk of age-related disease. In this study we tested for …
[HTML][HTML] DeepMAge: a methylation aging clock developed with deep learning
DNA methylation aging clocks have become an invaluable tool in biogerontology research
since their inception in 2013. Today, a variety of machine learning approaches have been …
since their inception in 2013. Today, a variety of machine learning approaches have been …