[HTML][HTML] Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia

D Lo Tartaro, A Neroni, A Paolini, R Borella… - Communications …, 2022 - nature.com
Aging is a major risk factor for developing severe COVID-19, but few detailed data are
available concerning immunological changes after infection in aged individuals. Here we …

Immune cell population and cytokine profiling suggest age dependent differences in the response to SARS-CoV-2 infection

L Aragon, A Iribarren-López, A Alberro… - Frontiers in …, 2023 - frontiersin.org
Aging population is at higher risk of developing severe COVID-19, including hospitalization
and death. In this work, to further understand the relationship between host age-related …

Age related differences in monocyte subsets and cytokine pattern during acute COVID-19—A prospective observational longitudinal study

A Pirabe, S Heber, WC Schrottmaier… - Cells, 2021 - mdpi.com
The COVID-19 pandemic drastically highlighted the vulnerability of the elderly population
towards viral and other infectious threats, illustrating that aging is accompanied by …

Differential dynamics of peripheral immune responses to acute SARS-CoV-2 infection in older adults

SA Lewis, S Sureshchandra, MZ Zulu, B Doratt… - Nature aging, 2021 - nature.com
In this study, peripheral blood mononuclear cells from young and old patients with COVID-
19 were examined phenotypically, transcriptionally and functionally to reveal age-, time-and …

Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients

J Westmeier, K Paniskaki, Z Karaköse, T Werner… - MBio, 2020 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell
response that most likely contributes to virus control in COVID-19 patients but may also …

Immune response to COVID-19 in older adults

M Jergović, CP Coplen, JL Uhrlaub… - The Journal of Heart and …, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the third highly
pathogenic coronavirus to emerge in the human population in last two decades. SARS-CoV …

I mmunosenescence and inflammaging: risk factors of severe COVID-19 in older people

AJ Pietrobon, FME Teixeira, MN Sato - Frontiers in immunology, 2020 - frontiersin.org
Old individuals are more susceptible to various infections due to immunological changes
that occur during the aging process. These changes named collectively as …

Distinct SARS-CoV-2 specific NLRP3 and IL-1β responses in T cells of aging patients during acute COVID-19 infection

SS Mahalingam, S Jayaraman, A Arunkumar… - Frontiers in …, 2023 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus
Disease 2019 (COVID-19) that presents with varied clinical manifestations ranging from …

Aging, inflammaging and immunosenescence as risk factors of severe COVID-19

AM Tizazu, HM Mengist, G Demeke - Immunity & Ageing, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused
by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is …

Remodeling of the immune response with aging: immunosenescence and its potential impact on COVID-19 immune response

LL Cunha, SF Perazzio, J Azzi, P Cravedi… - Frontiers in …, 2020 - frontiersin.org
Elderly individuals are the most susceptible to an aggressive form of coronavirus disease
(COVID-19), caused by SARS-CoV-2. The remodeling of immune response that is observed …