An epigenome‐wide DNA methylation study of patients with COVID‐19

S Zhou, J Zhang, J Xu, F Zhang, P Li… - Annals of human …, 2021 - Wiley Online Library
In the early 2000s, emerging SARS‐CoV‐2, which is highly pathogenic, posed a great threat
to public health. During COVID‐19, epigenetic regulation is deemed to be an important part …

Identification of COVID-19-associated DNA methylation variations by integrating methylation array and scRNA-Seq data at cell-type resolution

G Wang, Z Xiong, F Yang, X Zheng, W Zong, R Li… - Genes, 2022 - mdpi.com
Single-cell transcriptome studies have revealed immune dysfunction in COVID-19 patients,
including lymphopenia, T cell exhaustion, and increased levels of pro-inflammatory …

[HTML][HTML] Identification of whole-blood DNA methylation signatures and rules associated with COVID-19 severity

F Yuan, JX Ren, HP Liao, W Guo, L Chen… - Frontiers in Bioscience …, 2023 - imrpress.com
Background: Different severities of coronavirus disease 2019 (COVID-19) cause different
levels of respiratory symptoms and systemic inflammation. DNA methylation, a heritable …

Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection

G Barturen, E Carnero-Montoro… - Nature …, 2022 - nature.com
SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many
cases, to bilateral pneumonia, severe dyspnea, and in~ 5% of these, death. DNA …

Blood DNA methylation and COVID-19 outcomes

J Balnis, A Madrid, KJ Hogan, LA Drake, HC Chieng… - Clinical …, 2021 - Springer
Background There are no prior reports that compare differentially methylated regions of DNA
in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 …

Risk-focused differences in molecular processes implicated in SARS-CoV-2 infection: corollaries in DNA methylation and gene expression

C Konwar, R Asiimwe, AM Inkster, SM Merrill… - Epigenetics & …, 2021 - Springer
Background Understanding the molecular basis of susceptibility factors to the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health imperative. It …

A machine learning approach utilizing DNA methylation as an accurate classifier of COVID-19 disease severity

S Bowler, G Papoutsoglou, A Karanikas… - Scientific Reports, 2022 - nature.com
Since the onset of the COVID-19 pandemic, increasing cases with variable outcomes
continue globally because of variants and despite vaccines and therapies. There is a need …

Whole-Genome Methylation Sequencing Reveals that COVID-19–induced Epigenetic Dysregulation Remains 1 Year after Hospital Discharge

J Balnis, A Madrid, KJ Hogan, LA Drake… - American Journal of …, 2023 - atsjournals.org
Results Acute SARS-CoV-2 infection comprises 461 hypermethylated and 912
hypomethylated regions compared with healthy volunteers (Figure 1C). One year after …

Longitudinal study of DNA methylation and epigenetic clocks prior to and following test-confirmed COVID-19 and mRNA vaccination

APS Pang, AT Higgins-Chen, F Comite, I Raica… - Frontiers in …, 2022 - frontiersin.org
The host epigenetic landscape rapidly changes during SARS-CoV-2 infection, and evidence
suggest that severe COVID-19 is associated with durable scars to the epigenome …

Host methylation predicts SARS-CoV-2 infection and clinical outcome

IR Konigsberg, B Barnes, M Campbell… - Communications …, 2021 - nature.com
Background Since the onset of the SARS-CoV-2 pandemic, most clinical testing has focused
on RT-PCR. Host epigenome manipulation post coronavirus infection,–suggests that DNA …