Immunosenescence is the term commonly used to describe the multifaceted phenomenon
encompassing all changes occurring in the immune system during aging. It contributes to …

Advancing age is accompanied by profound changes in immune function; some are induced
by the loss of critical niches that support development of naïve cells (eg thymic involution) …

The immune system is a major regulatory system of the body, that is composed of immune
cells, immune organs, and related signaling factors. As an organism ages, observable age …

It is widely accepted that ageing is accompanied by remodelling of the immune system,
including reduced numbers of naïve T cells, increased senescent or exhausted T cells …

The number of elderly people is steadily increasing in most countries. Concomitantly, the
number of age-related diseases is unfortunately also increasing. One of the leading causes …

Cellular senescence is a critical part of human anti-tumor defence; however, the
accumulation of senescent cells with age underpins a wide range of pathologies. Senescent …

Aging is a natural physiological process that features various and variable challenges,
associated with loss of homeostasis within the organism, often leading to negative …

Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

It is now becoming apparent that the immune system undergoes age‐associated alterations,
which accumulate to produce a progressive deterioration in the ability to respond to …

Like all somatic tissues, the human immune system changes with age. This is believed to
result in an increased frequency of, and susceptibility to, infectious disease and to contribute …