Animal studies show aging varies between individuals as well as between organs within an
individual,,–, but whether this is true in humans and its effect on age-related diseases is …

Aging is a predominant risk factor for several chronic diseases that limit healthspan.
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …

Ageing is the single greatest cause of disease and death worldwide, and understanding the
associated processes could vastly improve quality of life. Although major categories of …

Biological aging of human organ systems reflects the interplay of age, chronic disease,
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …

The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

The global population of older peo-ple is growing at an unprecedented rate, with the number
of people over 65 years of age expected to reach 1.6 billion by 2050. Given that aging is a …

Pathway proteomics strategies measure protein expression changes in specific cellular
processes that carry out related functions. Using targeted tandem mass tags-based sample …

Accumulation of intracellular damage is an almost universal hallmark of aging. An improved
understanding of the systems that contribute to cellular protein quality control has shed light …

Older age is a strong shared risk factor for many chronic diseases, and there is increasing
interest in identifying aging biomarkers. Here, a proteomic analysis of 1301 plasma proteins …

We previously identified 529 proteins that had been reported by multiple different studies to
change their expression level with age in human plasma. In the present study, we measured …