Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease

VJ Lowe, ES Lundt, SM Albertson, SA Przybelski… - Alzheimer's & …, 2019 - Elsevier
Introduction Neuroimaging biomarkers are important for early diagnosis of Alzheimer's
disease, and comparing multimodality neuroimaging to autopsy data is essential. Methods …

Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes

JM Long, DW Coble, C Xiong, SE Schindler, RJ Perrin… - Brain, 2022 - academic.oup.com
Alzheimer's disease biomarkers are widely accepted as surrogate markers of underlying
neuropathological changes. However, few studies have evaluated whether preclinical …

[HTML][HTML] Regional correlations between [11C] PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort

SW Seo, N Ayakta, LT Grinberg, S Villeneuve… - NeuroImage: Clinical, 2017 - Elsevier
Imaging-pathological correlation studies show that in vivo amyloid-β (Aβ) positron emission
tomography (PET) strongly predicts the presence of significant Aβ pathology at autopsy. We …

Associations of the A/T/N profiles in PET, CSF, and plasma biomarkers with Alzheimer's disease neuropathology at autopsy

ZB Wang, L Tan, PY Gao, YH Ma, Y Fu… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION To examine the extent to which positron emission tomography (PET)‐,
cerebrospinal fluid (CSF)‐, and plasma‐related amyloid‐β/tau/neurodegeneration (A/T/N) …

The Alzheimer's disease neuroimaging initiative 2 PET core: 2015

WJ Jagust, SM Landau, RA Koeppe, EM Reiman… - Alzheimer's & …, 2015 - Elsevier
Introduction This article reviews the work done in the Alzheimer's Disease Neuroimaging
Initiative positron emission tomography (ADNI PET) core over the past 5 years, largely …

Relationships between biomarkers in aging and dementia

WJ Jagust, SM Landau, LM Shaw, JQ Trojanowski… - Neurology, 2009 - AAN Enterprises
Background: PET imaging using [18F] fluorodeoxyglucose (FDG) and [11C] Pittsburgh
compound B (PIB) have been proposed as biomarkers of Alzheimer disease (AD), as have …

Detecting earlier stages of amyloid deposition using PET in cognitively normal elderly adults

T Guo, SM Landau, WJ Jagust… - Neurology, 2020 - AAN Enterprises
Objective To examine the feasibility of using cross-sectional PET to identify cognitive
decliners among β-amyloid (Aβ)-negative cognitively normal (CN) elderly adults. Methods …

Age and neurodegeneration imaging biomarkers in persons with Alzheimer disease dementia

DS Knopman, CR Jack Jr, HJ Wiste, SD Weigand… - Neurology, 2016 - AAN Enterprises
Objective: To examine neurodegenerative imaging biomarkers in Alzheimer disease (AD)
dementia from middle to old age. Methods: Persons with AD dementia and elevated brain β …

Predicting long‐term clinical stability in amyloid‐positive subjects by FDG‐PET

L Iaccarino, A Sala, D Perani… - Annals of clinical …, 2019 - Wiley Online Library
Imaging biomarkers can be used to screen participants for Alzheimer's disease clinical trials.
To test the predictive values in clinical progression of neuropathology change (amyloid …

Diagnostic Accuracy of Amyloid versus 18F‐Fluorodeoxyglucose Positron Emission Tomography in Autopsy‐Confirmed Dementia

OH Lesman‐Segev, R La Joie, L Iaccarino… - Annals of …, 2021 - Wiley Online Library
Objective The purpose of this study was to compare the diagnostic accuracy of antemortem
11C‐Pittsburgh compound B (PIB) and 18F‐fluorodeoxyglucose (FDG) positron emission …