Aging is a major risk factor for many human diseases, and in vitro generation of human
neurons is an attractive approach for modeling aging-related brain disorders. However …

Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …

Aging is a major risk factor in many forms of late-onset neurodegenerative disorders. The
ability to recapitulate age-related characteristics of human neurons in culture will offer …

Sporadic Alzheimer's disease (AD) exclusively affects elderly people. Using direct
conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age …

Within just over a decade, human reprogramming‐based disease modeling has developed
from a rather outlandish idea into an essential part of disease research. While iPSCs are a …

In vitro generation of motor neurons (MNs) is a promising approach for modeling motor
neuron diseases (MNDs) such as amyotrophic lateral sclerosis (ALS). As aging is a leading …

Recent reports suggest that induced neurons (iNs), but not induced pluripotent stem cell
(iPSC)-derived neurons, largely preserve age-associated traits. Here, we report on the …

The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …

Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …

The adult central nervous system (CNS) contains resident stem cells within specific niches
that maintain a self-renewal and proliferative capacity to generate new neurons, astrocytes …