Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients

J Mertens, JR Herdy, L Traxler, ST Schafer… - Cell stem cell, 2021 - cell.com
Sporadic Alzheimer's disease (AD) exclusively affects elderly people. Using direct
conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age …

Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects

J Mertens, ACM Paquola, M Ku, E Hatch, L Böhnke… - Cell stem cell, 2015 - cell.com
Aging is a major risk factor for many human diseases, and in vitro generation of human
neurons is an attractive approach for modeling aging-related brain disorders. However …

[HTML][HTML] Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease

JR Herdy, L Traxler, RK Agarwal, L Karbacher… - Cell Stem Cell, 2022 - cell.com
The concept of senescence as a phenomenon limited to proliferating cells has been
challenged by growing evidence of senescence-like features in terminally differentiated …

Aging in a dish: iPSC-derived and directly induced neurons for studying brain aging and age-related neurodegenerative diseases

J Mertens, D Reid, S Lau, Y Kim… - Annual review of …, 2018 - annualreviews.org
Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …

REST and neural gene network dysregulation in iPSC models of Alzheimer's disease

K Meyer, HM Feldman, T Lu, D Drake, ET Lim, KH Ling… - Cell reports, 2019 - cell.com
The molecular basis of the earliest neuronal changes that lead to Alzheimer's disease (AD)
is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene …

Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

CJ Huh, B Zhang, MB Victor, S Dahiya, LFZ Batista… - elife, 2016 - elifesciences.org
Aging is a major risk factor in many forms of late-onset neurodegenerative disorders. The
ability to recapitulate age-related characteristics of human neurons in culture will offer …

Dedifferentiation and neuronal repression define familial Alzheimer's disease

AB Caldwell, Q Liu, GP Schroth, DR Galasko… - Science …, 2020 - science.org
Identifying the systems-level mechanisms that lead to Alzheimer's disease, an unmet need,
is an essential step toward the development of therapeutics. In this work, we report that the …

A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation

C Sheng, J Jungverdorben, H Wiethoff, Q Lin… - Nature …, 2018 - nature.com
Recent reports suggest that induced neurons (iNs), but not induced pluripotent stem cell
(iPSC)-derived neurons, largely preserve age-associated traits. Here, we report on the …

[PDF][PDF] RETRACTED: Directed Conversion of Alzheimer's Disease Patient Skin Fibroblasts into Functional Neurons

L Qiang, R Fujita, T Yamashita, S Angulo, H Rhinn… - Cell, 2011 - cell.com
Directed conversion of mature human cells, as from fibroblasts to neurons, is of potential
clinical utility for neurological disease modeling as well as cell therapeutics. Here, we …

Neural cell state shifts and fate loss in ageing and age-related diseases

L Traxler, R Lucciola, JR Herdy, JR Jones… - Nature Reviews …, 2023 - nature.com
Most age-related neurodegenerative diseases remain incurable owing to an incomplete
understanding of the disease mechanisms. Several environmental and genetic factors …