Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by
various cellular stresses and is known to play a pivotal role in tumour suppression. While …

Cellular senescence has emerged as a potent tumor suppression mechanism that restrains
proliferation of cells at risk for malignant transformation. Although senescent cells have …

Cellular senescence is a stress response associated with aging and disease, including
cancer. Senescent cells undergo a stable cell cycle arrest, undergo a change in morphology …

Cellular senescence is an established tumour-suppressive mechanism that prevents the
proliferation of premalignant cells. However, several lines of evidence show that senescent …

Introduction: Cellular senescence is a stable form of cell cycle exit. Though they no longer
divide, senescent cells remain metabolically active and secrete a plethora of proteins …

Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue
culture artefact by some researchers, senescence is now a major field of study. Although …

Simple Summary A fundamental feature of cellular senescence is the emergence of the
Senescence-Associated Secretory Phenotype (SASP), which represents a considerable …

Cancer is a devastating disease that increases exponentially with age. Cancer arises from
cells that proliferate in an unregulated manner, an attribute that is countered by cellular …

Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response
to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of …

Cellular senescence is a state of irreversible cell cycle arrest that can be induced by a
variety of potentially oncogenic stimuli, including DNA damage. Hence, senescence has …