Cancer is a devastating disease that increases exponentially with age. Cancer arises from
cells that proliferate in an unregulated manner, an attribute that is countered by cellular …

Cellular senescence has emerged as a potent tumor suppression mechanism that restrains
proliferation of cells at risk for malignant transformation. Although senescent cells have …

Several cancer interventions induce DNA damage and promote senescence in cancer and
nonmalignant cells. Senescent cells secrete a collection of proinflammatory factors …

Cellular senescence, a process of cell proliferation arrest in response to various stressors,
has been considered to be important factor in age-related disease. Identification of …

Introduction: Cellular senescence is a stable form of cell cycle exit. Though they no longer
divide, senescent cells remain metabolically active and secrete a plethora of proteins …

Simple Summary Cellular senescence consists of a permanent block of cell proliferation in
the presence of an active metabolism. It is a physiological process occurring when cells …

Cellular senescence is an established tumour-suppressive mechanism that prevents the
proliferation of premalignant cells. However, several lines of evidence show that senescent …

Cellular senescence, which is associated with aging, is a process by which cells enter a
state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive …

Cellular senescence is a state of durable cell arrest that has been identified both in vitro and
in vivo. It is associated with profound changes in gene expression and a specific secretory …

The senescence‐associated secretory phenotype (SASP), where senescent cells produce a
variety of secreted proteins including inflammatory cytokines, chemokines, matrix …