[HTML][HTML] The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective …
JE McElhaney, X Zhou, HK Talbot, E Soethout… - Vaccine, 2012 - Elsevier
Influenza remains the single most important cause of excess disability and mortality during
the winter months. In spite of widespread influenza vaccination programs leading to …
the winter months. In spite of widespread influenza vaccination programs leading to …
The immune response to influenza in older humans: beyond immune senescence
Despite widespread influenza vaccination programs, influenza remains a major cause of
morbidity and mortality in older adults. Age-related changes in multiple aspects of the …
morbidity and mortality in older adults. Age-related changes in multiple aspects of the …
[HTML][HTML] T-cell immunity to influenza in older adults: a pathophysiological framework for development of more effective vaccines
One of the most profound public health consequences of immune senescence is reflected in
an increased susceptibility to influenza and other acute respiratory illnesses, as well as a …
an increased susceptibility to influenza and other acute respiratory illnesses, as well as a …
Aging and impaired immunity to influenza viruses: implications for vaccine development
WM Liu, BAM van der Zeijst, CJP Boog… - Human …, 2011 - Taylor & Francis
Influenza infections are responsible for significant morbidity and mortality each year, with the
highest infection rates found in the elderly population. The main strategy to reduce the …
highest infection rates found in the elderly population. The main strategy to reduce the …
[HTML][HTML] Impact of aging and cytomegalovirus on immunological response to influenza vaccination and infection
The number of people over the age of 60 is expected to double by 2050 according to the
WHO. This emphasizes the need to ensure optimized resilience to health stressors in late …
WHO. This emphasizes the need to ensure optimized resilience to health stressors in late …
Immunosenescence and influenza vaccine efficacy
S Sambhara, JE McElhaney - Vaccines for Pandemic Influenza, 2009 - Springer
A number of protective immune functions decline with age along with physiological and
anatomical changes, contributing to the increased susceptibility of older adults to infectious …
anatomical changes, contributing to the increased susceptibility of older adults to infectious …
[HTML][HTML] Immunosenescence: influenza vaccination and the elderly
K Haq, JE McElhaney - Current opinion in immunology, 2014 - Elsevier
Highlights•Aging is associated with a decline in immune function termed 'immune
senescence'.•Effective influenza vaccines need to be developed for better protection the …
senescence'.•Effective influenza vaccines need to be developed for better protection the …
[HTML][HTML] Influenza vaccine responses in older adults
JE McElhaney - Ageing research reviews, 2011 - Elsevier
The most profound consequences of immune senescence with respect to public health are
the increased susceptibility to influenza and loss of efficacy of the current split-virus …
the increased susceptibility to influenza and loss of efficacy of the current split-virus …
[HTML][HTML] Aging and influenza vaccine-induced immunity
Immunosenescence is defined as the progressive deterioration of the immune system with
aging. Immunosenescence stifles the generation of protective B and T cell-mediated …
aging. Immunosenescence stifles the generation of protective B and T cell-mediated …
[HTML][HTML] Immunosenescence and challenges of vaccination against influenza in the aging population
AJ Reber, T Chirkova, JH Kim, W Cao, R Biber… - Aging and …, 2012 - ncbi.nlm.nih.gov
Influenza is an important contributor to morbidity and mortality worldwide. Accumulation of
genetic mutations termed antigenic drift, allows influenza viruses to inflict yearly epidemics …
genetic mutations termed antigenic drift, allows influenza viruses to inflict yearly epidemics …