[HTML][HTML] Health and aging: unifying concepts, scores, biomarkers and pathways

G Fuellen, L Jansen, AA Cohen, W Luyten… - Aging and …, 2019 - ncbi.nlm.nih.gov
Despite increasing research efforts, there is a lack of consensus on defining aging or health.
To understand the underlying processes, and to foster the development of targeted …

Molecular and physiological manifestations and measurement of aging in humans

SS Khan, BD Singer, DE Vaughan - Aging cell, 2017 - Wiley Online Library
Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

[HTML][HTML] Molecular and phenotypic biomarkers of aging

X Xia, W Chen, J McDermott, JDJ Han - F1000Research, 2017 - ncbi.nlm.nih.gov
Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging
are valuable tools to measure physiological age, assess the extent of 'healthy aging', and …

[HTML][HTML] Aging biomarkers and the measurement of health and risk

S Green, L Hillersdal - History and Philosophy of the Life Sciences, 2021 - Springer
Prevention of age-related disorders is increasingly in focus of health policies, and it is hoped
that early intervention on processes of deterioration can promote healthier and longer lives …

Promising biomarkers of human aging: In search of a multi-omics panel to understand the aging process from a multidimensional perspective

NA Rivero-Segura, OY Bello-Chavolla… - Ageing research …, 2020 - Elsevier
The aging process has been linked to the occurrence of chronic diseases and functional
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …

Association of biological age with health outcomes and its modifiable factors

WS Liu, J You, YJ Ge, BS Wu, Y Zhang, SD Chen… - Aging …, 2023 - Wiley Online Library
Identifying the clinical implications and modifiable and unmodifiable factors of aging
requires the measurement of biological age (BA) and age gap. Leveraging the biomedical …

[HTML][HTML] 60 years of healthy aging: on definitions, biomarkers, scores and challenges

LC Behr, A Simm, A Kluttig, A Grosskopf - Ageing Research Reviews, 2023 - Elsevier
ABSTRACT BACKGROUND AND OBJECTIVE As the proportion of aging people in our
population increases steadily, global strategies accompanied by extensive research are …

[HTML][HTML] A proposed panel of biomarkers of healthy ageing

J Lara, R Cooper, J Nissan, AT Ginty, KT Khaw… - BMC medicine, 2015 - Springer
Background There is no criterion reference for assessing healthy ageing and this creates
difficulties when conducting and comparing research on ageing across studies. A cardinal …

[图书][B] A life course approach to healthy ageing

D Kuh, R Cooper, R Hardy, M Richards, Y Ben-Shlomo - 2013 - books.google.com
Healthy ageing has long been a neglected area of epidemiological research as the
traditional focus has been on specific chronic diseases of older life. There is a growing …

Toward a systems biology framework for understanding aging and health span

GB West, A Bergman - Journals of Gerontology Series A …, 2009 - academic.oup.com
It is argued that aging research is at a stage where it could benefit greatly from a more
intense engagement with the perspectives emphasized by systems biology and complexity …